What is the normal function of the PAX8 gene?
During embryonic development, the PAX8 protein is thought to activate genes involved in the formation of the kidney and the thyroid gland. The thyroid gland is a butterfly-shaped tissue in the lower neck. It releases hormones that play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Following birth, the PAX8 protein regulates several genes involved in the production of thyroid hormones.(fromGenetics home reference)
It is now used a biomarker:
"PAX8 is expressed in Anaplastic Thyroid Carcinoma diagnosed by
fine needle aspiration. A study of three cases with histological
European Journal of Endocrinology, 07/01/2013