Saturday, December 7, 2013

DANCING WITH A GIANT NAMED: "THE SMALL HETERODIMER PARTNER"

There are 25000 genes in human cell approximately or give and/or take they say!
and only 20% are active at one given time they estimate.   But make no mistake about it, the rule of "company you keep" has not been as strong at play as it has in genes!   The Small Heterodimer PARTNER (SHP) really in the thick of it.  See it plays with one of the gene involved with a tissue which, once cancerous, lead to incurable cancer.   SHP interacts with non other than Hepatocyte nuclear factor 4 alpha (HNF4A).  And through this gene, it will reach a "wild gene" called "CREB-binding" which affects in its dealing to close to 50 genes ( Hell! all genes since it it is involved in the "breathing" of the cell!)  This small Heterodimer Partner is a misnomer, it is a GREAT Partner important in the function of all major Hormone from Androgen to Estrogen!  Touch this one, and you will feel the vibe!  If you know What I imply...

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