Already the first phase of results from the study funded partially by the CRBCM and MDHonors are completed. This is a study on lung cancer detection completed on 50 tissues provided by a tissue bank from the University of Virginia. Preliminary results coming from the University of Texas in El Paso seem to suggest that the genes involved appear consistently in all cancers no matter the stage of disease, types and race of individual bearing the disease. This fact is strong because it attest to the early occurrence of these mutations in the neoplastic transformation. It could subsequently point to cure if indeed these mutations are no longer detected since they appear undisturbed no matter the stage of disease.
The test could therefore detect non only the disease early, but cure of the disease, an unprecedented event...But don't let CRBCM jump ahead of its conclusions which have not been finalized until the publication of our first paper. Big heads will fight these finding as skepticism is stylish , remember the CRBCM is making the research happen, we do not micro-manage the outcomes! Facts are being fed to us, and they look promising! Our purpose is to explore, find the facts, and feed them to the community at large, and in the process learn! learn! and do the deed ......CRBCM, hard at work!
The second phase is to complete the same PCR based tests in matched serum (sera) of individuals who gave the tissues and spin the same tests to confirm the presence of these mutation in the serum. We intend to show that the mutations are detectable in blood. Should we demonstrate that the serum can give us the same result, early detection could be demonstrated in blood. There are caveats however and many have to do with determining that the findings are indeed found in lung cancer. Detection through PET in positive individual (who carry these mutations without evident mass) is just another hurdle we will have to face.
Corollary detection of specific mutations that makes tumors susceptible to Avastin will be conducted as part of this series. One of the curious fact performed by the researcher at UTEP is to use Actin as the reference standard. A fact that is peculiar and call for questions when we meet next to draft the preliminary draft of the 1st article. For CRBCM actin could potentially be used as a predictive Biomarker for Taxane and or Platinum effects! or is-it? We are at the entrance of bigger things we presume!
The CRBCM...advancing deliberately without big brother breathing down our neck. Science should be free of political pressures! It makes the thruth even more powerful...We are not closed to criticism, just bringing an argument!
What is important with this exercise is learning to do scientific stuff! That is what the people watching did not understand...yes the study has been done in some form, but doing stuff open new doors to a active mind, and a new institution!
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