Friday, February 7, 2014

What is cancer cure anyway.

It is easy to globally point out cure for cancer patients, if the patient is staying alive after a clear diagnosis of a cancer that is remote in somebody's life.  It is certainly nice to meet someone who "beat" cancer.  "oh 22 years ago, I had my colon removed for cancer".  You cannot imagine what it does to an Oncologist in particular.  This belief that the disease we face daily is "beatable".  We like to believe there is no cancer, or it is under the control of the immune "defense" or defense in general whether immune or not!
As gene goes, abnormality in terminal differentiation or genes that could be mutated and does not involve other interactions, appears to be the one we can cure.  Things, Mutations and abnormal complexes of genes that is localized, peripheral (at the membrane) or in a specific pathway once correctable can lead to cure.
Gleevec will address CML and diseases bearing similar, specific, and a certain KIT Mutation.  Incurrability seem to be brought in by a coexisting abnormality in gene that are "master modulators".  Gens who's functions cannot be clearly limited are tougher to control.
In breast cancer for example, the involvement of Casein Kinase gene is bad since this is a gene phosphorylating diffusely other genes, and the wrong one may be taken in the course,  the direct involvement of gnes placed in the epigenic area seems to suggest a poor outcome. There are gene called "master regulator or master genes" that appear critically irreversible.   EP 300 Mutation appears critically bad.  This is a "wild gene" interacting with all epigenetic events.  Its Mutation persistent after a "cure" means that cure is fundamentally questionable since it cannot be sustained!  These gene Mutation will one day be checked in every one after treatment to establish curability.  At that time, cure will be genetically achievable...EP300 is a strong example of course, it is not alone in this region....(NCOA, MEF,SP1, SIN3A etc...)  as compare to ie POT1 ( Telomere only)....

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