Sunday, April 6, 2014

few investigation questions in various diseases

What testosterone gene has to do with Hairy cell leukemia
What HLA has to do with Hairy cell leukemia (why the incidence in black is lower?)
Weight loss is linked to Cytokine discharges which interfere with Gluconeogenesis?
Organomegaly is linked to disturbances in the Catenins, protein mobility in the cells, or "cellular flagellation" ? but why?
Interesting this hairy cell, leads to hypocholesterolemia? what cytokine does this again? should it enter therapeutic trial?
Is it the Annexin A1,  what TRAP has to do, BRAF-V600E (activity of Vemurafenib in Hairy cell)
what cytokine lead to collagen or reticulin expression in this disease?
High dose interferon works in this disease!   Yes a Cytokine works (where is my Cytokine bank!)
The disease brings back a fundamental question, why susceptibility to infection, is it weakness in the mitochondria?is it the LYN gene, c-MYB or disturbance in the Ig.
Why vasculitis in this disease?  disturbance of G-proteins?

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