Going back and breaking down the process
1.cellular detachment: which will involve among othes genes the E-Cadherins
2.Movement of the cell, which will involve many processes, from genes involved in podocyte formation to protein movements inside the cell,
3.eluding autoimmune mechanisms to escape self destruction and recognition
4. adopting "mesodermal" conformation
5.swimming or displacing self along endothelial cells,
6.crossing vascular endothelium at site of seeding
7.Again avoiding detection from other cells (by providing overwhelming credentials!)
and winning the preferential nutrition game!
although most of the functions are concommitently acquired and accomplished (particularly through "embryonal" transformation or stem cell state or capability adoption), most functions are newly acquired through the neoplastic transformation (new CBF or gene binding ie BCR-Abl).
Suffice is to stress that to do these processes, the cell has to be sure it does not trigger Apoptosis and condemn itself to dying! So unless RAS /MEK/ERK is a driver pathway, many times it has to be shut down may be through the p66shc! This damn p66shc has been shown to help the neoplastic cell survive Anoikis.
wiki:"programmed cell death which is induced by anchorage-
CRBCM, let's go to work