El Paso non-existent on CPRIT Funding MAP

It is shocking to see, once again, that El Paso finds itself completely excluded from the Texas map of the Funding granted by CPRIT, the Cancer Prevention Research Institute of Texas.
                                              We intend to put El Paso on the Map again!

CPRIT MAY LOSE NCI SEAL OF APPROVAL!

The NCI announced that federal officials are looking into events at CPRIT.  It is unclear whether their evaluation will only lead to recommendations about the NCI seal of approval status, or whether they are searching for federal crimes at CPRIT.  Our fear for CPRIT's future is that a broader investigation will expose more irregularities in grant allocations, and that more people will be charged with criminal misconducts.  Voters were right to vote for CPRIT funding. Cancer needs to be met at higher intensity.  What voters  did not predict was that CPRIT will end up being taken over by "evil people" or "vultures and hyenas" in the words of a renowned Nobel Laureate who worked there.  What needs to occur at CPRIT is a complete purge which should change leardership and culture at CPRIT.  CRBCM would like to be invited to the conversation about the future of CPRIT.   We believe that broader measures and safeguards need to be implemented to not only preclude failures in grant allocations, but also to make sure CPRIT is more inclusive and responsive to minority concerns.  CPRIT has funded mainly Universities and Biotech companies in a race where even underdogs should be allowed to come up with the right ideas and should be given a chance!  CRBCM is such an underdog!   It is interesting to note that the departing chief executive wants to stay on until the next round of grant allocation.  The CRBCM is worried that his participation will be detrimental to our cause since we voiced our opinion.  It also will be ground for our next appeal. Let it be known!

So Many Americans have hoped to see work through our work:

"I hope all is well with you at the Coalition for the Reversal of Breast Cancer.

Although we haven’t connected in a while, I wanted to see how things were going with your anticipated new mobile project. Can you share any update with us? Do you need anything to help you with your project?

I would also like to introduce you to our new Sales Manager, Paul Simpson. Paul has over 25 years of customer service and support experience, and is now available to assist you as well.

Please let me know if Paul or I can do anything to help you make your mobile program a complete success for Coalition for the Reversal of Breast Cancer.

Feel free to contact Paul at PSimpson@ArmorMobile.com or 513-923-5627.

Thanks so much for the opportunity to help you “Go Mobile!” We hope to hear from you soon.

Best regards,"

But CPRIT did not get the message from El Paso!  Want us to be a UNIVERSITY to put people to work!
We have to find a way so CPRIT does not matter...New leadership is needed at CPRIT.   Universities have  transformed this in their back pocket.  We need to fight to change this EL Paso!

SEARCHING FOR A CANCER CURE

At CRBCM we believe that CPRIT is our necessary path to Victory over Cancer.
We also know we will not get its help this time around, not because we do not deserve the help but frankly because it is distracted.  Science is an objective thing.  It is a race.  You have the right move, the right stuff, you win, no matter where you come from.  It is the Olympics without steroids.

We at CRBCM have understood one thing, in the race for the cure, harnessing the force and laws of nature has an unparalleled advantage.  Forcing a cell to die can be done by telling and convincing it to die. Or blasting it and crossing our fingers and hoping it will die.  Chemotherapy did this mostly the second way but its success was partial.  Chemotherapy only works when it manages to finally talk the language.  Indeed, some chemotherapy manages to reach the syllables of the cellular language of death.

Sorting through the maze of messages, 2 powerful set of syllables come out:

1.  That if it fails to repair broken DNA and therefore does not perform GENE REPAIR, this fact will automatically activate your P53 leading to an automatic stop of the cell into its cycle division.  There is no loophole to this principle unless the P53 is abnormal.   Knowing this is powerful.  Now we understand why Cisplatin (and to some extent Gemcitabine)  is a powerful drug because it disrupts the DNA structure.  We also understand that cells with rapid repair of DNA, will brush it off, literally.

2.with further proof of principle, we believe that there is a second automatic message or syllables.
Destruction of Microfilaments (and therefore secondarily Microtubules in general) during cell division, leads to an automatic release of Caspase from the Mitochondria no matter what (and this is what includes the BCL-2 protection). It is in this law that resides the strength of Taxanes.  Medication that works even in resistant diseases such as Melanoma where Abraxane has a role.  Taxanes' limitations appear to be in the type of microtubules attacked. Medication that attacks Microfilament of the type involved in cell divison, where the Centromere is attached, appears to send a more determinant trigger to Caspase release.  This is where our interest comes in the Anti-kinesin.  We believe and predict that an effective anti-kinesin drug in combination with Taxane and Cisplatin/gemzar based combination, will harness best this law.  They will prove to be effective in cure because they will be effective in both treatment and maintenance settings.  This is also why the combination of Gemzar and Taxol has proven to be the strongest non platinum combination.

Following this principle, we believe now at CRBCM, that target therapy not following the laws of nature will have only 20-30% response rate, meaning effective in only the cells that lack loophole mechanisms.  (this also means because of phenotype heterogeneity, 70-85% of cells have potentially intrinsic loophole to any signal transduction target stimulation or blockage).

Lets keep our eyes on the ball, do not invest in stuff they are throwing at you!  More to come...

Comprehensive Health Intervention Program to Reverse Breast Cancer Mortality in El Paso, TX

We started the application process for a 3-year CPRIT Company Formation Award for our "Comprehensive Health Intervention Program to Reverse Breast Cancer Mortality in El Paso, TX":

CP130064, Application Abstract

This Comprehensive Health Intervention Program to Reverse Breast Cancer Mortality fills the need for a global breast cancer research, prevention,treatment and survivorship program for the underserved and underinsured Hispanic and African-American population on the greater Eastside of the city and county of El Paso.Primary goal is the reversal of breast cancer mortality.However,other health issues are expected to be discovered, we anticipate to find Diabetes Mellitus II, High blood pressure, Anemia, Obesity, Metabolic Syndrome and cancers of other sites than the Breast. Patients will be referred to nearest available care for those conditions and invited to join our cancer prevention program for free. Monitoring of their weight,education about healthy diet, physical activity and the benefit of screening will be offered to them. Laboratory research collaboration with Dr.Kirken, chair of the Dept of Biology, UTEP, to understand the specificity of the basal cell type breast cancer (a more aggressive cancer seen in minority populations), six molecular targets and the role of e-Cadherine and Metalloproteases.Mobile applications as developed by CPRIT grantee will help monitor patients' efforts and send critical updates on prevention, treatment schedule, track and encourage their healthy lifestyle efforts such as weight control, healthy diet and regular physical activity.The Survivorship Center will offer all standard medical services and a welcoming environment for patients in treatment.

CP130064, Executive Summary

The Coalition for the Reversal of Breast Cancer Mortality in African American Women is a Coalition about research, awareness, prevention, treatment and survivorship of Breast Cancer and all cancers, including targeted scientific research and a grassroots approach to increase screening for cancer, especially in the low income and under-insured population of El Paso, Texas, with a view to expand this new health care model to many other 'minority' populations across the United States and beyond.

The CRBCM’s reason for existence is to combat the famous “Breast Cancer Mortality Paradox” that has been known to exist for years. The paradox states that the incidence of Breast Cancer in minority populations (African American and Hispanic populations) is lower when compared with that in White women. However, their mortality rate is 40% to 70% higher than in White women.

This projects includes the Provision of Services to Patients and the Creation of Infrastructure for a Permanent and Comprehensive Cancer Center on the East side of El Paso to serve this population now and in the future in its needs for the best cancer treatments, most cost efficient medical and psycho-social care in a culturally appropriate setting where patients feel welcome and cared about like members of a large family to which they will stay linked as survivors in order to maintain the benefits of lifestyle changes including weight management, healthy diet, physical activity and regular follow-ups and screenings in their cancer care.

This project is unique as it to feed latest research findings as quickly as possible into research intervention programs in order to benefit patients in an easily accessible and understandable grassroots approach. The long-term benefits of a healthy lifestyle and education to raise awareness of risk factors together with a clear understanding of the benefits of appropriate screening routines will, hopefully, allow to improve the overall health of the El Paso population.

The cost/fee per patient care model is a dynamic one where all stakeholders push for efficiency and appropriateness of interventions and avoid wastage of precious resources wherever possible.

The use of mobile technology to communicate with the patient community in an active and regular way seems to be the future of an efficient and beneficial health care model. These technologies can also easily be tailored to language and socio-cultural specific sets of population and therefore increase the positive impact on public health of all these educational and improved healthy lifestyle behavior efforts.

CP130064 / Coalition for the Reversal of Breast Cancer Mortality in African American Women 

Many exciting Research and Prevention projects: CPRIT Abstracts 2012

http://abstracts.cprit2012.org/