Peroxisomes IPA: [pɛɜˈɹɒksɪˌsoʊmz][1] (also called microbodies) are organelles found in virtually all eukaryotic cells.[2] They are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, D-amino acids, polyamines, and biosynthesis of plasmalogens, i.e. ether phospholipids critical for the normal function of mammalian brains and lungs.[3] They also contain approximately 10% of the total activity of two enzymes in the pentose phosphate pathway, which is important for energy metabolism.[3] It is vigorously debated if peroxisomes are involved in isoprenoid and cholesterol synthesis in animals.[3] Other known peroxisomal functions include the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves,[4] glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.(Wikipedia)
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with our discussion on the PEX26 and Sufu, we are working on opportunities of interventions through the peroxisome!
Showing posts with label peroxisome proliferator-activated receptor gamma. Show all posts
Showing posts with label peroxisome proliferator-activated receptor gamma. Show all posts
Monday, September 23, 2013
Tuesday, August 20, 2013
THE "WEAKNESS" OF MEN HAS GOT TO BE IN THEIR ANDROGEN
One thing is certain, women seem to live longer than men...There seem to be many more widows than widowers! If you look at statistics of elderly who live the longest, you are more likely to find women than men. It is easy to say that men live a more stressful life and therefore die sooner, but one may also want to look into the main difference between men and women. And the Androgen level comes quickly to mind!
Androgen and related receptors are part of "wild genes", that is their effect here involves many genes downstream.
When you look at the span of genes which interact with the Androgen gene, one is struck by the deep epigenetic distribution of their effects!
One particular interacting gene stands out:
"NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma[4] and Androgen receptor.[ "(wikipedia)
The involvement of the PPAR gamma point to weakness of Antigen presentation and therefore a weakness in our defense mechanism. This perhaps opens the door to understanding why men having sex with men still have the highest Kaposi Sarcoma burden? I believe we are onto something here! look this up! NCOA4, a new target indeed!
Androgen and related receptors are part of "wild genes", that is their effect here involves many genes downstream.
When you look at the span of genes which interact with the Androgen gene, one is struck by the deep epigenetic distribution of their effects!
One particular interacting gene stands out:
"NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma[4] and Androgen receptor.[ "(wikipedia)
The involvement of the PPAR gamma point to weakness of Antigen presentation and therefore a weakness in our defense mechanism. This perhaps opens the door to understanding why men having sex with men still have the highest Kaposi Sarcoma burden? I believe we are onto something here! look this up! NCOA4, a new target indeed!
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