Tuesday, September 17, 2013

OTHER TARGETS! WHAT IN HELL IS LEUKEMEIA INHIBITOR FACTOR?

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THE LIST OF TARGET IS ENDLESS EVERYWHERE IN THE CELL THERE IS MUCH TO FIND OUT AND SCIENTISTS ARE SPEECHLESS LETS DELVE ON THIS ONE IN M...
Monday, September 16, 2013

Key advances

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*Microtubule Inhibitors (Taxanes, Ixabepilone, Erubilin) *Signs of cellular death (Shrinkage of cell, membrane bleb formation, DNA fragment...

JUST TO LET ME KNOW!

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Hi MUTOMBO, In the run up to Target TME ( 18-20 November , Boston) I've had the chance to speak with and interview researc...

THEORY IN CANCER PATHOLOGY

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Based on pathology findings in Bladder cancer and the progressive genetic abnormalities proclaimed to be happening in colon cancer it appear...
Sunday, September 15, 2013

Another BAD ACTOR ; a MET derivative!

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If you followed our fight for the cure, we are increasingly suggesting that, nature has given us its laws that we need to harvest and follo...
Saturday, September 14, 2013

Some of the interesting Basic questions in Oncology

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1.Understanding side effects better in order to design a response or treatment strategy! --------------------------------------------------...

A formidable opponent in the fight for the cure!

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The only purpose of the cell is to survive, and to do so it has ability to not only live without resources or Oxygen for that matter for a w...
Friday, September 13, 2013

fighting secondary malignancy post BRAF therapy

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To avoid secondary malignancy BRAF inhibitor should be associated to anti HSP90 (reduce stress associated side effects) or the MTOR Inhibi...

Next fight in the gene battle/computer models needed!

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Yes we have decipher the human genome But the epigenetic Zone is where things are happening what are the patterns of Methylated genes,  wh...

fighting the Cytokines!

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As we advance in our knowledge, it will be increasingly apparent that new biomarkers of disease will be defined  for a variety of diseases. ...

Recognition at CRBCM

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  Dear Dr. Mutombo Kankonde, You are one of the many valued members within our community celebrating a birthday this month. At the ...
Thursday, September 12, 2013

Melanoma: the chiken and egg story once more!

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If you read about Melanoma pathophysiology, the emphasis is clearly on p16/CDK2A and on p14ARF.  Other will emphasize the BRAF and PTENand B...

And, I am still heard!

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Contact us at support@radioairplay.com (800) 399-9318   Hello Clement Albert,   You have un...

If you are diabetic, water is your friend!

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It is really true that we keep we keep emphasizing that in Diabetes Mellitus sugar cannot be allowed in the cell, and that without the sugar...
Wednesday, September 11, 2013

WHAT'S IN THE NEWS!

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*reportedly dose dense Taxol carbo with Taxol given weekly at 80mg/m2 day 1,8,15 and Carbo full dose AUC -6 given every 3 weeks for 6 Cyc...
Tuesday, September 10, 2013

Clinical genetic questions in Hepatitis

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As we discuss deeper about the NOTCH and its activity, one of the disease syndrome that comes to mind is the pathobiology of conditions such...

UPDATE AFTER 1 YEAR OF CRBCM EXISTENCE!

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UPDATE OF FOLLOWERS/REVIEWS IN 1 YEAR OF CRBCM EXISTENCE , United States 16092 Russia 2060 Germany 1223 France...

PEOPLE WILL STOP SCIENCE FROM HAPPENING!

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The biggest stop to science progress is still HUMAN.  Full of politics and a little greed and above all full of competitive spirit.  You ask...
Monday, September 9, 2013

NOTCH NOTCH, who's there!?

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NOTCH NOTCH NOTCH every single where! Research at NIH reported that metastasis occur when the cancer cell has created an invasive extensio...
Sunday, September 8, 2013

OUR FASCINATION WITH THE NOTCH IS JUSTIFIED!

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If you read carefully with open mind everything we have written about the NOTCH you may have detected that Mutations at the NOTCH appears t...
Saturday, September 7, 2013

A SLEW OF INTERVENTIONS CAN AFFECT THE NOTCH

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Rather than sitting in awe before this dangerous phenomena that is the NOTCH, It is time to take a closer look at a comprehensive corrective...

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*FBW7/hCDC4, an ubiquitin ligase, a substrate of E3, It targets c-Myc, c-JUN and Notch for degradation through Ubiquitlation and proteasome...
Friday, September 6, 2013

Speculations on DPC4 gene!

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 "The K-ras oncogene is activated in approximately 90% of pancreatic adenocarcinomas, and the DPC4 (MADH4/SMAD4) tumor suppressor gene...

Activities at CRBCM

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*The CRBCM has moved to 11601 Pellicano Drive, suite A2 in EL PASO, same Zip code.  newer building Here we finally have direct frontage to ...
Thursday, September 5, 2013

In Cancer target therapy, BIG IS NOT NECESSARILY BETTER.

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Scientists have long understood that our fascination with major pathways in the cell should be modulated and attention to smaller and inter...
Wednesday, September 4, 2013

It is time to take it or leave it! SEASONAL FLU VACCINE!

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   DATE:           September 4, 2013      SUBJECT:     2013-14 Seasonal Influenza Vaccination Program   It's that time aga...

FROM HYPOXIA TO CANCER/ HTLV1 (RAPID COMPLICATION OF CELLULAR EVENTS)

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What is really going on in the tissue is that there is a relative Hypoxia in the tissue.  These Hypoxic conditions are exacerbated in Obese ...

MORE SUPPUTATIONS IN GENETIC TARGETING THERAPY

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My deep investigation into Hypoxia has led to an interesting set of clinical questions What is again the role of Mitotane in the treatment ...
Monday, September 2, 2013

The trenches of stress

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Whether the stimuli to stress be physical (heat, radiation, cold etc) or autoimmune or infectious(Interleukins, TNF,other cytokines and cycl...