Monday, June 30, 2014

THE BEST IS YET TO COME! ONE THRUTH BUT MANY HIDDEN LAYERS (THE CELL).

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Dig this by REN et al! and you will understand that the anti-VEGF is still JUST the begining of the membrane story: "The small Ras-rela...

treatment in Gastric Cancer and G-E Junction

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Although Ramucirumab a " fully human monoclonal antibody (IgG1) developed for the treatment of solid tumors. It is directed against th...
Saturday, June 28, 2014

Genes proposed for Molecular testing by Jennel Hodge at al!

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ABL  AKT1   ALK   APC   ATM   BRAF    CDH1 CDKN2A  CSF1R    CTNNB1   EGFR    ERB2    ERB4   EZH2 FBXW7    FGFR1   FGFR2   FGFR3   FLT3    ...

speculations

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Could cytoxan-Oxaliplatin +/- antiandrogen    Vs Cytoxan -Oxaliplatin +/-Nexavar makes a difference for Hepatoma yes I know the French  h...
Thursday, June 26, 2014

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As target therapy continue to advance, increasingly first line treatment will be a combination of these therapy and cost will be increasing...
Wednesday, June 25, 2014

Keep it alive! 3 steps ahead...

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No need to create a new Hospital no need to create a new cancer center but transform a wing of a old hospital in a cancer treatment wing ...
Tuesday, June 24, 2014

Further speculation on lipid deposition

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Before I start, let me be clear that the following is clear speculations but it is a speculation based on preliminary facts thats seems to ...
Monday, June 23, 2014

Down the road of many cancers, our understanding is still increasing....

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It is increasingly puzzling that Gene suppression could be one of the most powerful way to induce cancer and most likely to affect cellular ...

Medication Index

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Abilify depression Invokana,Canagliflozin is an SGLT2 inhibitor, DM Patanol,watery eyes, allergic conjunctivitis Topiramate: seizures, M...

Activities at CRBCM

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*About to start Oncology work in warsaw Indiana for the first 2 weeks of July... *Working with local University on CPRIT project *Finalizi...
Saturday, June 21, 2014

Rare case of Femoro-Acetabular Impingement

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A 41 year old Hispanic woman was referred to us for evaluation 10 days after an MVA.  She was hit on the driver side  (WHICH THE LEFT IN THE...
Thursday, June 19, 2014

Quality Measures for Diabetic patient

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In Diabetic patients 1.HbA1c 2.Neurologic eval 3.Foot care 4.Weight Control (BMI) 5.Retinopathy Monitor 6.Renal preservation/Use of AC...

Opinion on Melanoma treatment

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*Having listen to the treatment on Melanoma it appears to me the V600 or BRAF positive patient have a short lived progression free because...
Wednesday, June 18, 2014

post of the day

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PALOMA-1 Trial Finds Palbociclib/Letrozole Doubles Progression-Free Survival in Metastatic Breast Cancer May 1, 2014, Volume 5, Issue 7 g...

And I knew a Cytokine bank is what we need in El Paso

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Intralesional Cytokine Therapy in Cutaneous Melanoma: A Call for Clinical Trials By E. George Elias, MD, PhD November 1, 2013, Volume ...
Tuesday, June 17, 2014

One Case to struggle with...

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A 60 year old smoker presents with Dysphagia, mid epigastric pain and weight loss cutting through the chase, a work-up suggested an obstruc...

some genes to watch through careful trials!

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( CLCN7 ,  (defectictive resorption of immature bones), interacts with MITF which in turn interacts with LEF1, the same LEF1 that needs to s...
Sunday, June 15, 2014

Openings on cancer cure I

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The challenge of cancer cure remains closely linked to the mechanism underlying the cause of the neoplastic process that caused any particul...
Saturday, June 14, 2014

Some Cellular activity in neoplasms

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"The researchers also found that the human genome is peppered with more than 1,200 large regions that are consistently devoid of DNA m...
Thursday, June 12, 2014

For Neuropathy

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1.Duloxetine 2.Nortryptilin 3.Neurontin 4.Baclofen, Ketamin gel! from the literature!
Wednesday, June 11, 2014

Gene interference!

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There is now strong evidence that YWHAG gene abnormality are strong initiator of cancer (biomarker) that PAK-1 disruption could dissociate ...
Sunday, June 8, 2014

pondering on this case

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A 57 year old male presented in December 2013 to a general clinic complaining of abdominal and diarrhea that was intermittently bloody, the ...
Monday, June 2, 2014

Alpha Anti-trypsin, interesting questions

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A tour de force of nature going awry, or a simple application of cellular principles that raises questions? Is it a liver disease or a lung...

Careful what you read or should you have a second look into cytokines? YKL-40

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There are certain genes that cause concern and are deemed prognosis. That is their presence clearly induces a bad prognosis because they cau...
Thursday, May 29, 2014

don't finger CRBCM, we are trying!

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I was literally stopped to be questioned about statements on my blog! it is a blog the statements although based on facts are inted to sh...

progress at CRBCM!

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The CRBCM is continuing to advance... we are completing our mission in Louisville Kentucky, with expansion into Indiana, from Madison to Se...
Tuesday, May 27, 2014

what that's means in termes of gene abnormality for humira

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The drug increases chances of getting lymphoma viral infection (hepatitis) TB CNS complications allergies immune reactions worsening o...

The case of Urothelial Cancer

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Greater east cancer center was referred a case of a 42 year old man with history of previous admission for Peptic Ulcer disease who had repo...
Monday, May 26, 2014

Case in point : Urothelial Cancer with plasmacytoid histology

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>the tumor is bad news 1.It is Multicentric, Multifocal, and therefore metastatic at time of diagnosis 2.Its signet rings characteristi...
Sunday, May 18, 2014

Genes with dangerous behaviors

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1.Do remember that in the selection of genes to silence, find one that causes a Malformation  when mutated or deficient i.e the BRAF gene ...