IT IS INVOLVED IN CRAZINESS (ALZHEIMER'S)
BUT YET IT KEEPS DOING ITS THING.
CAN WE STOP IT ELECTIVELY?
WE ARE WORKING HARD!
FYN
From Wikipedia, the free encyclopedia
| FYN oncogene related to SRC, FGR, YES | |||||||||||
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 PDB rendering based on 1a0n. |
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| Identifiers | |||||||||||
| Symbols | FYN; SLK; SYN; p59-FYN | ||||||||||
| External IDs | OMIM: 137025 MGI: 95602 HomoloGene: 48068 ChEMBL: 1841 GeneCards: FYN Gene | ||||||||||
| EC number | 2.7.10.2 | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 2534 | 14360 | |||||||||
| Ensembl | ENSG00000010810 | ENSMUSG00000019843 | |||||||||
| UniProt | P06241 | P39688 | |||||||||
| RefSeq (mRNA) | NM_001242779 | NM_001122892 | |||||||||
| RefSeq (protein) | NP_002028 | NP_001116364 | |||||||||
| Location (UCSC) | Chr 6: 111.98 – 112.19 Mb |
Chr 10: 39.37 – 39.57 Mb |
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| PubMed search | [1] | [2] | |||||||||
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein.
Interactions
FYN has been shown to interact with:- ADD2[6]
- Alpha-tubulin 3C,[7]
- BCAR1[8][9]
- Cbl gene[10][11]
- CBLC[12]
- CD36[13][14]
- CD44[15]
- CDH1[16]
- CHRNA7[17]
- Colony stimulating factor 1 receptor[18]
- C-Raf[19]
- CTNND1[16][20]
- DLG4[21][22]
- Dystroglycan[23]
- EPHA8[24]
- Fas ligand[25][26]
- FYB[27][28]
- GNB2L1[29][30]
- GRIN2A[21][22][31][32]
- ITK[33][34]
- Janus kinase 2,[35]
- KHDRBS1[36][37]
- Nephrin[38][39]
- PAG1[40]
- PIK3R2[41]
- PRKCQ[42]
- Protein unc-119 homolog[43]
- PTK2[44][45]
- PTK2B[46][47][48]
- RICS[49]
- SH2D1A[50][51]
- SKAP1[28][52][53]
- Syk[11]
- Tau protein[7](ALZHEIMER LOCATED HERE PEOPLE!)
- TNK2,[54]
- TrkB[55]
- TRPC6[56]
- Tyrosine kinase 2[57]
- Wiskott-Aldrich syndrome protein[58][59][60]
- ZAP-70[61]
References (WIKIPEDIA)
WITH THIS MANY INTERACTIONS, IT IS A CRITICAL GENE, BUT WATCH OUT NOW, IT NEEDS TO BE HANDLED WITH CARE. HIT IT ONLY IN A VERY SELECTIVE FASHION NOW! OR YOU LOSE THE HOST!
another crazy gene
Androgen receptor has been shown to interact with:
- AKT1,[38]
- BAG1,[39][40][41]
- Beta-catenin,[42][43][44][45][46][47]
- BRCA1,[48][49]
- C-jun,[50]
- Calmodulin 1,[51]
- Caveolin 1,[52]
- CDK9,[53]
- COX5B,[54]
- CREB-binding protein,[55][56][57][58]
- Cyclin D1,[59][60]
- Cyclin-dependent kinase 7,[61]
- Death associated protein 6,[62]
- Deleted in Colorectal Cancer,[63]
- EFCAB6,[64]
- Epidermal growth factor receptor,[65][66]
- FOXO1,[67]
- GAPDH,[68]
- Gelsolin,[69]
- GNB2L1,[70]
- GSK3B,[71]
- HDAC1,[72]
- HSP90AA1,[73][74]
- HTATIP,[72]
- MAGEA11,[75][76]
- MED1,[77]
- MYST2,[78]
- NCOA1,[43][79][80]
- NCOA2,[42][57][75][81][82]
- NCOA3,[81][83][84]
- NCOA4,[38][82][85][86][87][88][89][90][91]
- NCOA6,[92]
- NCOR2,[42][93][94]
- NONO,[57]
- PA2G4,[95]
- PAK6,[96][97]
- PATZ1,[98]
- PIAS2,[99][100]
- PRPF6,[101]
- PTEN,[102]
- RAD9A,[103]
- RANBP9,[104]
- RCHY1,[105]
- Retinoblastoma protein,[106][107]
- RNF14,[82][85][108][109]
- RNF4,[98][110][111]
- SART3,[112]
- SMAD3,[113][114][115]
- Small heterodimer partner,[116]
- Src,[102][117][118]
- SRY,[119]
- STAT3,[120][121]
- SVIL,[122]
- Testicular receptor 2,[123]
- Testicular receptor 4,[124]
- TGFB1I1,[85][125]
- TMF1,[126]
- TRIM68,[127]
- UBE2I,[42][43][128][129][130][131]
- UXT,[132] and
- ZMIZ1.[133]
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