slide II. RECOGNITION OF FUNDAMENTAL PHYSIOLOGIC / GENETIC BASIS OF TBI

1.ALL CELLULAR EVENTS AND DISEASES ARE GENETICALLY BASED
2.RECOGNITION THAT EFFECT OF TBI ARE IMMEDIATE AND DELAYED
        a. IMMEDIATE  :-COUP AND CONTRECOUP! (Bi-axial deformation of Neurons)
                           - CONCUSSION,
                           - COMPRESSION
        b. DELAYED
                           -ANOXIA
                          -STRESS INDUCED
                          -INFLAMMATORY :   ACTIVATION OF FACTOR TRANSCRIPTION                      AND CYTOKINE RELEASE!

3.TISSUE AFFECTED (primarily and/or secondarily)
==LONG PROJECTING AXONE
==MYELIN
==BLOOD VESSEL
==SUSCEPTIBILITY TO CYTOKINES BY VARIOUS BRAIN AREAS
==ACTIVITY AT VARIOUS BRAIN RECEPTORS