Thursday, February 18, 2016
It gets complicated
from Myriad"Myriad’s newest companion diagnostic, myChoiceTM HRD,
is an algorithmic measurement of three biomarkers associated with
homologous recombination deficiency, combined with next-generation
sequencing of the BRCA1 and BRCA2 genes in the tumor.
The three biomarkers, loss of heterozygosity (LOH), telomeric allelic
imbalance (TAI), and large-scale state transitions (LST), have all been
individually shown to be associated with BRCA1/2 deficiency.1"
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