1. Identifying best chemotherapy drugs in patients with Mutation in the NOTCH pathway?
Taxotere?
association with Her-2 overexpression and use of Herceptin
NF-kB blocker
or AKT blocker.
Histone de-acetylator
2. Understanding the patterns of Metastasis between epithelial (squamous) (more local recurrence) Vs AdenoCA (more distant recurrence in Esophageal cancer? Genes at play.
Does mesenchymalization dictate or drive long distance metastasis?
3. Mitomycin in NFKB amplification/Mutations
Showing posts with label NFkB. Show all posts
Showing posts with label NFkB. Show all posts
Tuesday, November 5, 2013
Tuesday, February 5, 2013
NOMENCLATURE OF GENES AND PATHWAYS INVOLVED IN BUTEIN INHIBITIONS: IKK and Sirtuin
IKK:
The subunit to be inhibited for the activation of the Nuclear factor and pathway NF-kB which has versatile transforming capacity to combat, escape and resist various attackers including infection and chemotherapy. Inhibition here reduces the cell capacity to adapt. It appears that the Transcription factor NFkB is sitting there in the Cytosol totally inactive, touch the IKK through phosphorylation, wakes the NFkB which spring into motion and unleashes its power. One of the best described pathway flow is TNF posphorylation of IKK which detaches and goes on to being ubiquitinated and degraded through the Proteasome. detachment of the IKK lead to a free NFkB kinase which enter the nucleus to unleash all kinds of genes of defense. DO REMEMBER that upstream NFkB go through MEK (also involved in Angiogenesis) to reach MAP3K and you can see how through networking of these pathways the phenomena gets global.
Sirtuin:
This compound is SIRT1, it is activated by BUTEIN
Butein actually activate SIRT1 and may induce aging in the cell. Remember Butein by activating Sirtuin will have a role in Diabetes, Gout, Alzheimer dementia, and Amyloid related disease. Butein, a versatile anti-inflammatory drug with effect on NAD (Nicotinamid), and may be a Histone De-acetylase inhibitor. This stuff has potential!
The subunit to be inhibited for the activation of the Nuclear factor and pathway NF-kB which has versatile transforming capacity to combat, escape and resist various attackers including infection and chemotherapy. Inhibition here reduces the cell capacity to adapt. It appears that the Transcription factor NFkB is sitting there in the Cytosol totally inactive, touch the IKK through phosphorylation, wakes the NFkB which spring into motion and unleashes its power. One of the best described pathway flow is TNF posphorylation of IKK which detaches and goes on to being ubiquitinated and degraded through the Proteasome. detachment of the IKK lead to a free NFkB kinase which enter the nucleus to unleash all kinds of genes of defense. DO REMEMBER that upstream NFkB go through MEK (also involved in Angiogenesis) to reach MAP3K and you can see how through networking of these pathways the phenomena gets global.
Sirtuin:
This compound is SIRT1, it is activated by BUTEIN
Butein actually activate SIRT1 and may induce aging in the cell. Remember Butein by activating Sirtuin will have a role in Diabetes, Gout, Alzheimer dementia, and Amyloid related disease. Butein, a versatile anti-inflammatory drug with effect on NAD (Nicotinamid), and may be a Histone De-acetylase inhibitor. This stuff has potential!
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