PHENOMENA AT THE "NOTCH"

THE NOTCH PROVIDES MANY OPPORTUNITIES FOR CURE OR INTERVENTIONS FOR THE CURE IN THOSE CANCERS:

1. WE KNOW THE Numb INHIBITS IT
2. IT IS REGULATED BY DELTEX
3. IT REGULATES BMP10, NRG1, Ephrin-B2
(CHECK OUT Rex-1)

INFLUENCED BY DII4

LIGAND DELTA STIMULATE IT

DLL1, DLL3, JAG-1,2

INDUCE PROLIFERATION BY ACTING ON c-MYC, p21, HES FAMILY

REDUCES AVASTIN EFFECT BY OVER-EXPRESSION OF VEGFR2

INTERACT WITH HEY GENE AND   Cbf-1

PRESENILINS 1,2

THE BEAUTY IS THAT BEING A RECEPTOR, IT'S GLYCOSYLATION IS CRUCIAL TO ITS FUNCTION, DESTROY POFUT-1 AND SOMETHING WILL HAPPEN  OR IMPAIR O-GLYCOSYLATION AND THE RECEPTOR FUNCTION IS KAPUTT!

FIBROBLAST GROWTH FACTOR 10,

WE ARE LOOKING AT ALL THIS AT CRBCM,
BUT KNOW THIS: YOU ARE DANCING WITH DEATH WHILE AT THE "NOTCH"