Bromocrptine and Colchine could potentially enter the fight against triple negative breast Cancer (maintenance therapy)

Following our first article about Triple Negative Breast cancer as it could be related to the ROLE OF PROLACTIN, It is evident that Medications that depress the secretion of Prolactin will come into play soon in the maintenance therapy of triple negative Breast cancer if proof of concept is maintained.  One of the comment made was that Prolactin and its receptor could not possibly be the culprit despite the fact that the gene for the prolactin receptor is a "wild gene".  We still believe we are on the right path.  Indeed one of the major role of Prolactin is to promote genes related to Casein.  Many Hormones including Glucocorticoids and potentially (or more likely Insulin) do promote Casein related genes.  One of these genes is Casein Kinase, a major source of substrate phosphorylation for critical Compounds

"Casein kinase 2, alpha 1 has been shown to interact with CHEK1,^[4][5] FGF1,^[6] CDC25B,^[7] CREB-binding protein,^[8] Activating transcription factor 2,^[8] C-Fos,^[8] MAPK14,^[9] RELA,^[10] PIN1,^[11] PLEKHO1,^[12] CSNK2B,^{[12][13][14][15][16]} PTEN,^[17] ATF1,^[8] TAF1,^[18] UBTF,^[19] DNA damage-inducible transcript 3,^[20] Basic fibroblast growth factor,^[6] APC,^[21] HNRPA2B1^[22] and C-jun".^[8]wikipedia

if you did not see the wnt listed, read again my blog of yesterday, because between the frizzled and dishevelled, one of them vividly interacts with CK2 gene.  To find inhibitors to this CK2, leave quickly the US and fly to Padua, Italy:

"Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 (‘casein kinase-2’)

Edited by Giulio Superti-Furga

• Stefania Sarno^{a, 1},
• Helen Reddy^{b, 1},
• Flavio Meggio^a,
• Maria Ruzzene^a,
• Stephen P. Davies^b,
• Arianna Donella-Deana^a,
• David Shugar^c,
• Lorenzo A. Pinna^{a, ,}

• ^a Department of Biological Chemistry, University of Padua, and CNR Biomembrane Research Center, viale G. Colombo 3, 35121 Padua, Italy"
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• SO, FORGET ESTROGEN, PROGESTERONE, WELCOME   CASEIN RECEPTORS IN TRIPLE NEGATIVE BREAST CANCERS!
• AND IF YOU DID NOT SEE P300 AMONG THE PHOSPHORYLATED by CK2...GO BACK TO THE DRAWING BOARD! and if you did not notice UBTF, please read wikipedia again!
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• CRBCM PUSHING RESEARCH IN BREAST CANCER!  WELL KIND OF, THE FINANCIAL INSTITUTIONS THAT CAN HELP US ARE STILL SITTING ON THEIR HANDS FOR POLITICAL REASONS!