When you study Arterosclerosis
when you study Breast cancer
Molecular movement inside the cell is important
then you come across this:
"
On binding a ligand the protein and ligand are internalized. This
internalization is independent of macropinocytosis and occurs by an
actin dependent mechanism requiring the activation Src-family kinases,
JNK and Rho-family GTPases.[29] Unlike macropinocytosis this process is not affected by inhibitors of phosphatidylinositol 3-kinase or Na+/H+ exchange.
CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.[30]
Recently, CD36 was linked to store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2[31]" wikipedia
this is about CD36
and you start thinking, am I in the belly of the Beast.
Research has shown!
PERK
!
!
Phosphorylate
!
!
PABP(interaction)---elf4 (ternary complex) which activates IRES (HnRNPC1)
CD36-------Glucose
!
!
Reinitiation of protein translation
then there is a GNC4
a general initiation factor
A general translation factor
ATF4
work to do!
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