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Showing posts with label cancer research. Show all posts
Showing posts with label cancer research. Show all posts
Wednesday, October 30, 2013
IN A BIG ANNOUNCEMENT TODAY: CPRIT IS FREE AGAIN! CONGRATULATIONS!
Sunday, April 21, 2013
CPRIT: A former congressman joined its board
CPRIT: A former congressman joined its board
PETE GEREN a well known former Democratic congressman from the Fort Worth counties, has been named to the CPRIT governing board. He will bring much needed dynamism and fortitude to CPRIT.
He was nominated by the Speaker of the House of Representative Joe Straus to replace TOM LUCE who is now the new chief operating officer of the O’Donnell Foundation since April 1st, 2013. The Dallas foundation of philanthropist Peter O’Donnell and his
wife Edith, is reported to have contributed more than $600
million over the past 30 years to support scientific research and education. Their link to CPRIT has been controversial at best!In other related news, Jay Maguire, a lobbyist with long ties to Tobacco companies, was hired 3 months ago by the CPRIT Foundation, now called the Texas Cancer Coalition.
Observers have been proud of changes and the new direction that CPRIT has taken overall. We wish this important organization for Texas well!
Thursday, April 4, 2013
WE CONTINUE TO BE STOPPED IN OUR PROGRESS BECAUSE OF LACK OF FUNDING
IN THE UNITED STATES THE SCARCITY OF FUNDING HAS BECOME A HINDRANCE TO THE CURE PROMPTING THE AMERICAN CANCER SOCIETY TO LAUNCH A TELEVISION CAMPAIGN ASKING PEOPLE TO TAKE THIS CAUSE BACK TO THE STREET. THE AMERICAN CONGRESS IS SHACKLED IN DIVISIONS THAT HAVE NOW BECOME VISCERAL AND NONSENSICAL. AMERICA HAS LOST ITS DREAMERS AND THEREFORE ITS INSPIRING IDEALS. UNDER THE PRETENSE OF FINANCIAL PRUDENCE, DREAMS ARE ALLOWED TO DIE, CURE LET TO ESCAPE ONE MORE DAY, AND CANCER VICTIMS ARE LET TO DIE IN THE PROCESS! (WE NEED LINCOLN BACK!)
"LET'S GET LOUD" THE CANCER AGENCY ADVOCATES, AND THE CRBCM SUPPORTS THE MOVEMENT!
ANOTHER COMPONENT TO THE PROBLEM, WITH SCARCITY COME MORE POLITICAL FAVORS, MORE DISCRIMINATION AND DISPARITY IN GRANT ALLOCATIONS. THE CRBCM DOES NOT EXPECT ANYTHING AT PRESENT. THE IRS IS STILL FIGHTING US BY SHACKLING OUR 501 STATUS. SUPPRESSION OF MINORITY RESEARCH POTENTIAL COMES IN ALL UGLY FORMS! WE WILL NOT BACK DOWN UNTIL THEIR PLAY BECOME IRRELEVANT TO THE COURSE OF HISTORY! CPRIT HAS PLAYED FAVORITISM, LOOK WHERE THEY ARE...DO THE RIGHT THING PEOPLE, NO ONE HAS REACHED THE MOON BY FAULTY MATH BECAUSE NATURE IS WATCHING! AT THE CRBCM, THE FIGHT IS ON, WE ARE NOT GOING ANYWHERE AND STAY IN
THE GAME UNTIL OUR VOICE IS HEARD, UNTIL OUR ENEMIES BECOME IRRELEVANT AND UNTIL WE ARE ALLOWED TO RISE!
"LET'S GET LOUD" THE CANCER AGENCY ADVOCATES, AND THE CRBCM SUPPORTS THE MOVEMENT!
ANOTHER COMPONENT TO THE PROBLEM, WITH SCARCITY COME MORE POLITICAL FAVORS, MORE DISCRIMINATION AND DISPARITY IN GRANT ALLOCATIONS. THE CRBCM DOES NOT EXPECT ANYTHING AT PRESENT. THE IRS IS STILL FIGHTING US BY SHACKLING OUR 501 STATUS. SUPPRESSION OF MINORITY RESEARCH POTENTIAL COMES IN ALL UGLY FORMS! WE WILL NOT BACK DOWN UNTIL THEIR PLAY BECOME IRRELEVANT TO THE COURSE OF HISTORY! CPRIT HAS PLAYED FAVORITISM, LOOK WHERE THEY ARE...DO THE RIGHT THING PEOPLE, NO ONE HAS REACHED THE MOON BY FAULTY MATH BECAUSE NATURE IS WATCHING! AT THE CRBCM, THE FIGHT IS ON, WE ARE NOT GOING ANYWHERE AND STAY IN
THE GAME UNTIL OUR VOICE IS HEARD, UNTIL OUR ENEMIES BECOME IRRELEVANT AND UNTIL WE ARE ALLOWED TO RISE!
Tuesday, April 2, 2013
Update on CPRIT Grant Moratorium
Update on CPRIT Grant Moratorium
In a March 19 letter to the Oversight Committee, the Governor, Lieutenant Governor, and Speaker of the House authorized CPRIT to move forward with the 25 researcher recruitment grants approved by the Oversight Committee in August and December 2012.
Once information becomes available regarding the remaining August and December awards that are awaiting final contracts, an update will be posted on CPRIT’s website.
We are grateful to the Governor, Lt. Governor, and Speaker for allowing CPRIT to proceed with these important recruitment awards. We will continue to work with them and all members of the Legislature to make sure they have the information they need to determine how they want CPRIT to operate going forward. We have worked hard to regain trust with our elected officials and the citizens of Texas. We take this action as evidence that some progress has been made and we will continue to work to strengthen this trust during the coming weeks and months.
In a March 19 letter to the Oversight Committee, the Governor, Lieutenant Governor, and Speaker of the House authorized CPRIT to move forward with the 25 researcher recruitment grants approved by the Oversight Committee in August and December 2012.
Once information becomes available regarding the remaining August and December awards that are awaiting final contracts, an update will be posted on CPRIT’s website.
The following is a statement released March 20 from Wayne Roberts, Interim Executive Director of CPRIT:
The Cancer Prevention and Research Institute of Texas has been informed that state leadership has authorized the agency to move forward with the 25 researcher recruitment grants approved by the CPRIT Oversight Committee in August and December. These grants have been awaiting final contracts, pursuant to the moratorium instituted by the Governor, Lt. Governor and Speaker on December 18. Each of these grants has been certified as being reviewed and approved using appropriate processes and procedures.We are grateful to the Governor, Lt. Governor, and Speaker for allowing CPRIT to proceed with these important recruitment awards. We will continue to work with them and all members of the Legislature to make sure they have the information they need to determine how they want CPRIT to operate going forward. We have worked hard to regain trust with our elected officials and the citizens of Texas. We take this action as evidence that some progress has been made and we will continue to work to strengthen this trust during the coming weeks and months.
Saturday, March 23, 2013
CPRIT, a flawed organization?
CPRIT, a great organization in principle, but fundamentally flawed or skewed. By now we know it is a university funding organization. The idea that CPRIT will ever become what it was imagined to be has been irreversibly given a blow to the cheek. It still is to be known that it will ever recover. Its funding shackled by politicians who now own this dream-like organization!
And this is very unfortunate because there is increasing evidence that cancer is curable as target therapy has opened a new round of successful therapies. The CPRIT debacle has left deep wounds and critics see in the remnant a living organization bent on continuing the same dance! The abrupt closure of a few fictitious companies is a tell-tale sign of what is to come unless an uninvolved visionary leader takes control. Political appointees are unfortunately what we see. And the objectivity and look from the outside is lost, new wind is not coming and CPRIT's old culture stays the same! All we will see is a tighter dance, but globally the same dance. Cancer Cure will escape the people one more time!
New researchers are coming to CPRIT backed Universities, but every university has a culture and pressures that shape these researchers. And the old CPRIT failed to control the events happening after money had been given. Nothing tells the observer that those changes have been put in place. We know by now that CPRIT is an exclusive university funding source by design (reviewers have strong university ties and see the world in this light and prism) and that the private medical and research sector is excluded. We should not mention our organization, we have been technically banned given our criticism...CPRIT only wants to hear good things! But the truth is that it is refusing to hear what would and could make it a grand organization. CPRIT's responsibilities should not stop with the granting of funds, but making sure the implemented projects match CPRIT's objectives and policies even deep into the course of the projects' implementation. That fix has not occurred. The risk is to end up with disparate and futile findings (probably commercial). When you look around, there are antibodies commercially available everywhere, however no one is using them in a cohesive plan, and without its own plan for the cure, CPRIT is at the mercy of Universities. And these politicians at the head of CPRIT WILL NOT SEE THE DANGER OF BEING PULLED ONE WAY OR THE OTHER BY POWERFUL UNIVERSITIES. CPRIT needs to pull away from this cosyness with Universities to achieve its goal quicker. It is playing safe by relying on Universities, but it is loosing its own perspective and is positioning itself further as being only a university instrument ripe for another round of "cleaner" abuses.
And this is very unfortunate because there is increasing evidence that cancer is curable as target therapy has opened a new round of successful therapies. The CPRIT debacle has left deep wounds and critics see in the remnant a living organization bent on continuing the same dance! The abrupt closure of a few fictitious companies is a tell-tale sign of what is to come unless an uninvolved visionary leader takes control. Political appointees are unfortunately what we see. And the objectivity and look from the outside is lost, new wind is not coming and CPRIT's old culture stays the same! All we will see is a tighter dance, but globally the same dance. Cancer Cure will escape the people one more time!
New researchers are coming to CPRIT backed Universities, but every university has a culture and pressures that shape these researchers. And the old CPRIT failed to control the events happening after money had been given. Nothing tells the observer that those changes have been put in place. We know by now that CPRIT is an exclusive university funding source by design (reviewers have strong university ties and see the world in this light and prism) and that the private medical and research sector is excluded. We should not mention our organization, we have been technically banned given our criticism...CPRIT only wants to hear good things! But the truth is that it is refusing to hear what would and could make it a grand organization. CPRIT's responsibilities should not stop with the granting of funds, but making sure the implemented projects match CPRIT's objectives and policies even deep into the course of the projects' implementation. That fix has not occurred. The risk is to end up with disparate and futile findings (probably commercial). When you look around, there are antibodies commercially available everywhere, however no one is using them in a cohesive plan, and without its own plan for the cure, CPRIT is at the mercy of Universities. And these politicians at the head of CPRIT WILL NOT SEE THE DANGER OF BEING PULLED ONE WAY OR THE OTHER BY POWERFUL UNIVERSITIES. CPRIT needs to pull away from this cosyness with Universities to achieve its goal quicker. It is playing safe by relying on Universities, but it is loosing its own perspective and is positioning itself further as being only a university instrument ripe for another round of "cleaner" abuses.
Sunday, March 3, 2013
INCREASING NEED OF A TISSUE BANK IN EL PASO.
With the increased need for cancer genetic studies, there is an increasing need of a Tissue bank in El Paso.
This town is at the border with Mexico has somewhat of an homogeneous population of a minority population which is most of the time under-represented in most clinical trials. Here, 80% of the population is Hispanic, therefore increasing the chance to have a nice homogenous cohort for clinical trials in a minority population. We have completed a study on risk factors for Breast cancer as perceived by the local population. Full Analysis is awaiting funding. Data is still sitting in the office while we are busy seeing and helping patients to survive. A recent Collaboration with the UTEP (University of Texas in El Paso) statistics laboratory will relaunch this and maybe we will then be able to publish the full study.
Risk perception here is very much influenced by the local culture and practices centered on "family" and "religion".
The UTEP Border Biomedical Research Center has a clean cell line maintained, but they want to do more. But we are here in a low income city and easily ignored. President Obama stopped by last year and the city voted for him, but nothing else has happened much since. CPRIT gave 0.2% of its cancer research funding to the 4th largest City in Texas, EL PASO, a city of 800,000 people! That is all we get: a glance from Authorities! El Paso is largely ignored. El Paso Women had to organize a sit-out in protest in front of the White House last year. They were basically ignored and dismissed with political promises that have never materialized.
We need a Tissue bank here in El Paso, everybody knows it, but brushes it off!
The city is home to Fort Bliss, undoubtedly the largest military base receiving most likely the largest portion of returning soldiers. But the medical facilities here are rather modest, fraught with financial issues and a hesitant medical leadership! Even the needed new Beaumont Hospital construction is tied up in court with contractors fighting over the opportunities instead of being built!
We need a tissue bank, if you know any one who can help....! call 915-307-3354
With the increased need for cancer genetic studies, there is an increasing need of a Tissue bank in El Paso.
This town is at the border with Mexico has somewhat of an homogeneous population of a minority population which is most of the time under-represented in most clinical trials. Here, 80% of the population is Hispanic, therefore increasing the chance to have a nice homogenous cohort for clinical trials in a minority population. We have completed a study on risk factors for Breast cancer as perceived by the local population. Full Analysis is awaiting funding. Data is still sitting in the office while we are busy seeing and helping patients to survive. A recent Collaboration with the UTEP (University of Texas in El Paso) statistics laboratory will relaunch this and maybe we will then be able to publish the full study.
Risk perception here is very much influenced by the local culture and practices centered on "family" and "religion".
The UTEP Border Biomedical Research Center has a clean cell line maintained, but they want to do more. But we are here in a low income city and easily ignored. President Obama stopped by last year and the city voted for him, but nothing else has happened much since. CPRIT gave 0.2% of its cancer research funding to the 4th largest City in Texas, EL PASO, a city of 800,000 people! That is all we get: a glance from Authorities! El Paso is largely ignored. El Paso Women had to organize a sit-out in protest in front of the White House last year. They were basically ignored and dismissed with political promises that have never materialized.
We need a Tissue bank here in El Paso, everybody knows it, but brushes it off!
The city is home to Fort Bliss, undoubtedly the largest military base receiving most likely the largest portion of returning soldiers. But the medical facilities here are rather modest, fraught with financial issues and a hesitant medical leadership! Even the needed new Beaumont Hospital construction is tied up in court with contractors fighting over the opportunities instead of being built!
We need a tissue bank, if you know any one who can help....! call 915-307-3354
Thursday, February 28, 2013
AT CPRIT,
The foundation has been deemed a NON Government body by the District Attorney.
A senator had requested that files from the CPRIT Foundation be opened under Disclosure rules and the Foundation had refused to comply, claiming it was a non government institution because of its private funding source. The district Attorney was asked to rule on the matter. Now she has ruled for the foundation.
Reportedly, the Senator has not given up and has requested the Senate make the foundation a Government institution. We at CRBCM are just watching the power play. These games will just delay the fight for the CURE (if any). Meanwhile budget discussion for new funding for CPRIT was once again by-passed, and the remaining 183 Million $ are still frozen. There is a growing concern about the future of CPRIT and Health programs are caught in this messy uncertainty!
2 major officials are still waiting to be deposed by investigators while the criminal investigation is ongoing! They reportedly were not heard by the senate because doing so would have given them automatic immunity protections.
The Audit is still ongoing and still discovering new irregularities, with over 300 more funded projects to review, they have their work cut out!
The foundation has been deemed a NON Government body by the District Attorney.
A senator had requested that files from the CPRIT Foundation be opened under Disclosure rules and the Foundation had refused to comply, claiming it was a non government institution because of its private funding source. The district Attorney was asked to rule on the matter. Now she has ruled for the foundation.
Reportedly, the Senator has not given up and has requested the Senate make the foundation a Government institution. We at CRBCM are just watching the power play. These games will just delay the fight for the CURE (if any). Meanwhile budget discussion for new funding for CPRIT was once again by-passed, and the remaining 183 Million $ are still frozen. There is a growing concern about the future of CPRIT and Health programs are caught in this messy uncertainty!
2 major officials are still waiting to be deposed by investigators while the criminal investigation is ongoing! They reportedly were not heard by the senate because doing so would have given them automatic immunity protections.
The Audit is still ongoing and still discovering new irregularities, with over 300 more funded projects to review, they have their work cut out!
Wednesday, February 27, 2013
INTERESTING ARTICLES. GO TO THEM!
1.Plastin3 is a novel marker for circulating tumor cells undergoing
the epithelial-mesenchymal transition and is associated with colorectal
cancer prognosis
Cancer Research, 02/21/2013
(APPARANTLY THIS IS NOT FOUND NATURALLY IN NORMAL BLOOD)
| 2Multicentre phase II trial of bevacizumab combined with docetaxel carboplatin for the neoadjuvant treatment of triple-negative breast cancer (KCSG BR-0905) | ||||||||||||||||||||||||||
| Annals of Oncology 02/06/2013 | STUDY COMPLETED IN KOREA |
Monday, February 25, 2013
CPRIT DID HOLD A MEETING TODAY AS PROMISED
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It is our understanding that this meeting was intended to wrap up paperwork with the winners of the last
round of CPRIT deliberations. The giving of money is however still under moratorium. I refuse to comment on the winners because it was the same old dance with the MD Anderson getting 42% of all contracts!
The meeting came under a lot of tension and uncertainty. With news that there won't be an annual meeting at CPRIT this year. With exclusion from the Texas budget in 2014 and 2015, CPRIT future is more than uncertain. The dance seems to wrap up despite everybody's belief in the reason for CPRIT.
The leadership at CPRIT has been so shaken that we are still waiting to see new initiatives to depict and profile a new CPRIT. The time would have been now to start a new posture and new direction. Wrapping up old deals without showing a new organization was an opportunity missed. Particularly when a new 1 Million Dollar contract is revealed to be just as fraudulently awarded as other previously described. If you give me time and again money, I just may find my way to $100,000 furniture. We are human after all!
NEW CPRIT PLEASE COME OUT OF THE SHADOW OF THE OLD CPRIT ! THE SENATORS ARE WATCHING, PLEASE CONVINCE THEM!
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It is our understanding that this meeting was intended to wrap up paperwork with the winners of the last
round of CPRIT deliberations. The giving of money is however still under moratorium. I refuse to comment on the winners because it was the same old dance with the MD Anderson getting 42% of all contracts!
The meeting came under a lot of tension and uncertainty. With news that there won't be an annual meeting at CPRIT this year. With exclusion from the Texas budget in 2014 and 2015, CPRIT future is more than uncertain. The dance seems to wrap up despite everybody's belief in the reason for CPRIT.
The leadership at CPRIT has been so shaken that we are still waiting to see new initiatives to depict and profile a new CPRIT. The time would have been now to start a new posture and new direction. Wrapping up old deals without showing a new organization was an opportunity missed. Particularly when a new 1 Million Dollar contract is revealed to be just as fraudulently awarded as other previously described. If you give me time and again money, I just may find my way to $100,000 furniture. We are human after all!
NEW CPRIT PLEASE COME OUT OF THE SHADOW OF THE OLD CPRIT ! THE SENATORS ARE WATCHING, PLEASE CONVINCE THEM!
Friday, February 22, 2013
Keep CPRIT focused on research
Express-News Editorial Board
Updated 4:17 pm, Wednesday, January 30, 2013
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For a politician who once said that government should “trust
capital markets and (the) private sector to make the decisions, and let
the consumers pick winners and losers,” Gov. Rick Perry certainly has had a change of heart.
As a candidate seeking the Republican presidential nomination, Perry was critical of the idea that government can create jobs and opposed government transfers of wealth. As governor of Texas, it's a different story.
Perry has been a staunch advocate of the Texas Enterprise Fund and the Emerging Technology Fund as tools for economic development. Taxpayer dollars bankroll both funds which, as the governor's website describes the Texas Enterprise Fund, “help attract new jobs and investment to the state.”
Perry's job creation claims, however, haven't stood up to scrutiny. His manipulation of the Texas Enterprise Fund, including circumvention of the fund's advisory panel to award $50 million to a controversial project at Texas A&M University, his alma mater, and the distribution of grants to a large number of companies whose principals are significant donors to his campaigns earned Perry charges of “crony capitalism” from his GOP competitors.
That sketchy history is enough to oppose Perry's efforts to transform the Cancer Prevention and Research Institute of Texas into another public investment vehicle from which, he told the Houston Chronicle, “wealth can be created.” What's worse, changing CPRIT's mission to commercialization and wealth creation amounts to a bait and switch with taxpayers.
Voters approved up to $3 billion for CPRIT in 2007 with the understanding that it would fund “research in Texas to find the causes of and cures for cancer.” The ballot measure, Proposition 15, said nothing about commercialization.
CPRIT's grant-making process is already a source of controversy. The institute's leaders and lawmakers should resist pressure from Perry to shift CPRIT's mission away from basic research. When it comes to commercializing cures and treatments, let the market of medical professionals and cancer patients pick winners and losers.
As a candidate seeking the Republican presidential nomination, Perry was critical of the idea that government can create jobs and opposed government transfers of wealth. As governor of Texas, it's a different story.
Perry has been a staunch advocate of the Texas Enterprise Fund and the Emerging Technology Fund as tools for economic development. Taxpayer dollars bankroll both funds which, as the governor's website describes the Texas Enterprise Fund, “help attract new jobs and investment to the state.”
Perry's job creation claims, however, haven't stood up to scrutiny. His manipulation of the Texas Enterprise Fund, including circumvention of the fund's advisory panel to award $50 million to a controversial project at Texas A&M University, his alma mater, and the distribution of grants to a large number of companies whose principals are significant donors to his campaigns earned Perry charges of “crony capitalism” from his GOP competitors.
That sketchy history is enough to oppose Perry's efforts to transform the Cancer Prevention and Research Institute of Texas into another public investment vehicle from which, he told the Houston Chronicle, “wealth can be created.” What's worse, changing CPRIT's mission to commercialization and wealth creation amounts to a bait and switch with taxpayers.
Voters approved up to $3 billion for CPRIT in 2007 with the understanding that it would fund “research in Texas to find the causes of and cures for cancer.” The ballot measure, Proposition 15, said nothing about commercialization.
CPRIT's grant-making process is already a source of controversy. The institute's leaders and lawmakers should resist pressure from Perry to shift CPRIT's mission away from basic research. When it comes to commercializing cures and treatments, let the market of medical professionals and cancer patients pick winners and losers.
Thursday, February 21, 2013
ACTIVITIES AT CRBCM
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Invitation
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MEETING WAS ABOUT SETTING THE POLICY TO BE FOLLOWED FOR TREATMENTS OF CRBCM PATIENTS. DR ZEINA NAHLEH, DIRECTOR OF THE INFUSION CENTER WAS PRESENT. THIS WAS A GOOD MEETING. CRBCM PATIENTS WILL BE WELL ATTENDED WITH QUALITY CARE OFFERED AT THE UNIVERSITY MEDICAL CENTER IN EL PASO! AND THANK YOU!
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Invitation
| Feb 20 (1 day ago) | | ||
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Images are not displayed. Display images below - Always display images from JCaldera@umcelpaso.org
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Your Agenda for Thu Feb 21, 2013
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MEETING WAS ABOUT SETTING THE POLICY TO BE FOLLOWED FOR TREATMENTS OF CRBCM PATIENTS. DR ZEINA NAHLEH, DIRECTOR OF THE INFUSION CENTER WAS PRESENT. THIS WAS A GOOD MEETING. CRBCM PATIENTS WILL BE WELL ATTENDED WITH QUALITY CARE OFFERED AT THE UNIVERSITY MEDICAL CENTER IN EL PASO! AND THANK YOU!
Tuesday, November 13, 2012
Reflections at CRBCM
Reflections at CRBCM.
Life has a way to complicate things
and people who dwell in politics do not know when to stop.
Science is strong when it is full of objectivity,
let the people who know how to do things, work free of politics.
It does not matter how big you are, if you are always wrong, you will become irrelevant to history,
will be brushed aside because the world will realize who you really are...
let people with the vision lead the way because human adventure will have to sustain itself through unwelcome noise and unfriendly misadventure. The vision remains the best protector of the adventure and of the place where the adventure tries to reach. Don't get distracted, if a door is closed, keep looking for one that will open. For as long as there is hope, the vision is possible. Just find a way to survive a little longer, until your door opens, until the opposition comes to its senses, until your voice is heard, until the critics realize you are not going away, until their bet fails, until they become irrelevant to the race. Because it will happen without failing. The truth always wins over falsification. Politicians always get entangled in their own games. Unless they speak the truth, they will keep on cheating until they unravel. Give them time to realize it! If you conspire behind closed door, believe me, over time, those with you could one day change allegiance given shifting conditions of life, and whatever perfidy will come to light. You will lose control of the consequences and outcome. History did not bring you to your position to fail, win by acting on your conscience and do things to improve the human condition, not reign by division and creating enemies. I am saddened to meet people who proclaim as true the lies they have been fed, spreading division and blunt racism. Racism is the resort of those with no argument and intrinsic value. There is no wrong in being proud of yourself as long as you do not impose those values on people who cannot see your positions and change to satisfy you. Imposing an unfair burden on others is never right. Level the field and give to a chance to all. That is the American way!
Life has a way to complicate things
and people who dwell in politics do not know when to stop.
Science is strong when it is full of objectivity,
let the people who know how to do things, work free of politics.
It does not matter how big you are, if you are always wrong, you will become irrelevant to history,
will be brushed aside because the world will realize who you really are...
let people with the vision lead the way because human adventure will have to sustain itself through unwelcome noise and unfriendly misadventure. The vision remains the best protector of the adventure and of the place where the adventure tries to reach. Don't get distracted, if a door is closed, keep looking for one that will open. For as long as there is hope, the vision is possible. Just find a way to survive a little longer, until your door opens, until the opposition comes to its senses, until your voice is heard, until the critics realize you are not going away, until their bet fails, until they become irrelevant to the race. Because it will happen without failing. The truth always wins over falsification. Politicians always get entangled in their own games. Unless they speak the truth, they will keep on cheating until they unravel. Give them time to realize it! If you conspire behind closed door, believe me, over time, those with you could one day change allegiance given shifting conditions of life, and whatever perfidy will come to light. You will lose control of the consequences and outcome. History did not bring you to your position to fail, win by acting on your conscience and do things to improve the human condition, not reign by division and creating enemies. I am saddened to meet people who proclaim as true the lies they have been fed, spreading division and blunt racism. Racism is the resort of those with no argument and intrinsic value. There is no wrong in being proud of yourself as long as you do not impose those values on people who cannot see your positions and change to satisfy you. Imposing an unfair burden on others is never right. Level the field and give to a chance to all. That is the American way!
Sunday, October 14, 2012
CLINICAL HYPOTHESIS IN CANCER RESEARCH AND COMMERCIALIZATION:
CLINICAL HYPOTHESIS IN CANCER RESEARCH AND COMMERCIALIZATION:
Of 186,000 Prostate cancers diagnosed each year, only 29,000 patients will die of this disease. In fact 70% of men over 80 years of age may be found with Prostate Cancer. Most will not die of this cancer. This fact has made almost futile the testing for prostate cancer in elderly patients. How does one chose who should be followed closely or treated? In other words how do you know what prostate cancer to observe versus which one to actually treat? In more scientific terms, which are the predictive factors that would prompt us to act versus observe the cancer? To make the matter more confusing, the success of PSA (prostate Specific Antigen) testing has complicated the issue. It has led to over-diagnosis, and experts are now recommending to use PSA findings with caution.
One thing is for sure: the difference between a benign and malignant tumor is that the malignant ones spread and invade our body. This is called "ability to metastasize". It is by invading other organs that cancer causes these organs to fail and finally causing death of the patient. Researchers have now started to look at cancer cells to try to predict which ones will spread and therefore kill the individual.
The Hypothesis:
For a cancer to spread, it has to detach itself from its surroundings and create a way to where it wants to go. Scientists have suggested that wherever a cell is located, it is maintained in place by ADHESION MOLECULES which tie them to the location. To make its move, the cancer cell has to lose these molecules.
This is why E-Cadherin has to be reduced by the cell, so that it can free itself from this environment. The question now is: Is a REDUCTION OF E-CADHERIN A PREDICTOR OF BAD CANCER? IN OTHER WORDS, SHOULD WE BE TESTING FOR THE REDUCTION OF E-CADHERIN IN PROSTATE CANCER TO PREDICT WHICH ONES NEEDS INTERVENTION? This is thought provoking.
P120 and beta- catenins are 2 molecules which could potentially be surrogates of cancer metastasis...who knows for sure!
After it has freed itself, the cancer cell has to move through tissues, it uses enzymes to break through the fibers. Some of these enzymes are called METALLOPROTEINASE. The current question is: SHOULD WE BE MEASURING LEVELS OF METALLOPROTEINASES TO DETECT CANCER CELLS ON THE MOVE?
These questions have been raised, it is time to work.
We could actually improve current means of screening for cancer by checking for reduction of E-Cadherin and increase of metalloproteinase in the tumor or blood if this is possible. Potential for commercialization is high if we can conquer this detection technology. "lets go to work!
12/3/2012
METASTATASIS AND SEEDING INTO NEW OR INVADED TISSUE
When the cancer cell reaches the new location, it uses the TGF beta to help its growth and to create exceptional advantage for its growth versus surrounding tissue. This Lead scientists to conclude that TGF beta presence is a sign of resistant disease. When in facts, it is first a late sign of metastasis already COMPLETED, TGF beta seems to be a sign of SEEDING INTO A NEW LOCATION. TGF BETA NOT ONLY STIMULATE GROWTH BUT COULD BE AN INHIBITORY PROTEIN FOR THE HOST DEFENSE AND REJECTION.
QUESTION:
SHOULD TGF BETA INCREASE BE THE THE SIGN OF SEEDING VS LATE STEP OF METASTASIS. WE BELIEVE THAT BY THE TIME TGF BETA IS BEING ELEVATED, SEEDING HAS ALREADY OCCURRED.
Of 186,000 Prostate cancers diagnosed each year, only 29,000 patients will die of this disease. In fact 70% of men over 80 years of age may be found with Prostate Cancer. Most will not die of this cancer. This fact has made almost futile the testing for prostate cancer in elderly patients. How does one chose who should be followed closely or treated? In other words how do you know what prostate cancer to observe versus which one to actually treat? In more scientific terms, which are the predictive factors that would prompt us to act versus observe the cancer? To make the matter more confusing, the success of PSA (prostate Specific Antigen) testing has complicated the issue. It has led to over-diagnosis, and experts are now recommending to use PSA findings with caution.
One thing is for sure: the difference between a benign and malignant tumor is that the malignant ones spread and invade our body. This is called "ability to metastasize". It is by invading other organs that cancer causes these organs to fail and finally causing death of the patient. Researchers have now started to look at cancer cells to try to predict which ones will spread and therefore kill the individual.
The Hypothesis:
For a cancer to spread, it has to detach itself from its surroundings and create a way to where it wants to go. Scientists have suggested that wherever a cell is located, it is maintained in place by ADHESION MOLECULES which tie them to the location. To make its move, the cancer cell has to lose these molecules.
This is why E-Cadherin has to be reduced by the cell, so that it can free itself from this environment. The question now is: Is a REDUCTION OF E-CADHERIN A PREDICTOR OF BAD CANCER? IN OTHER WORDS, SHOULD WE BE TESTING FOR THE REDUCTION OF E-CADHERIN IN PROSTATE CANCER TO PREDICT WHICH ONES NEEDS INTERVENTION? This is thought provoking.
P120 and beta- catenins are 2 molecules which could potentially be surrogates of cancer metastasis...who knows for sure!
After it has freed itself, the cancer cell has to move through tissues, it uses enzymes to break through the fibers. Some of these enzymes are called METALLOPROTEINASE. The current question is: SHOULD WE BE MEASURING LEVELS OF METALLOPROTEINASES TO DETECT CANCER CELLS ON THE MOVE?
Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
Eleni Apostolidou1*)These questions have been raised, it is time to work.
We could actually improve current means of screening for cancer by checking for reduction of E-Cadherin and increase of metalloproteinase in the tumor or blood if this is possible. Potential for commercialization is high if we can conquer this detection technology. "lets go to work!
12/3/2012
METASTATASIS AND SEEDING INTO NEW OR INVADED TISSUE
When the cancer cell reaches the new location, it uses the TGF beta to help its growth and to create exceptional advantage for its growth versus surrounding tissue. This Lead scientists to conclude that TGF beta presence is a sign of resistant disease. When in facts, it is first a late sign of metastasis already COMPLETED, TGF beta seems to be a sign of SEEDING INTO A NEW LOCATION. TGF BETA NOT ONLY STIMULATE GROWTH BUT COULD BE AN INHIBITORY PROTEIN FOR THE HOST DEFENSE AND REJECTION.
QUESTION:
SHOULD TGF BETA INCREASE BE THE THE SIGN OF SEEDING VS LATE STEP OF METASTASIS. WE BELIEVE THAT BY THE TIME TGF BETA IS BEING ELEVATED, SEEDING HAS ALREADY OCCURRED.
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