A NICE EXAMPLE OF TARGETING THERAPY,

While one will quickly think of CML and the Gleevec story as a hit and run case (I really meant Home Run case) of successful targeting therapy, there is a forgotten case.   Secretly  but concretly established is the case of the GIANT CELL TUMOR OF THE BONE.  The condition is rare but can be a pain in the neck if you pardon my french!  In one percent of cases, it can even Metastasize!  Go figure! for what is described a "benign" disease
It is cause by the RANKL, those receptor that call the Osteoclast like cells to come in the theater and destroy the bone!  well we found DENOSUMAB, and it gave us 80% response rate. nothing to be ashamed about.   DENOSUMAB A GOOD TARGET THERAPY!


AND LIKE IN GOOD COMMERCIAL, THEY GIVE YOU IN SMALL PRINTS (yes but watch for headache,nausea,,hypocalcemia, hypophosphatemia and osteonecrosis of the jaw) AND HOPE YOU DID NOT SEE IT!