GENES IN SARCOMA (CONTINUE)

GNAS-1
This is the perfect example that intermediaries in a pathways can be critical
when a receptor is linked to its ligand, the chemical reaction goes nowhere without some G-protein taking the flash and transmitting this spark to Adenylate Cyclase.   When you see danger, you stand to fight back or run to safety because of GNAS gene.  Believe Me Adrenaline rush will no do you a thing without GNAS, the Gene is so important they gave a Nobel Prize to the guy who found it.
" . A Nobel Prize was awarded to Earl Sutherland in 1971 for discovering the key role of AC-III in human liver, where adrenaline indirectly stimulates AC to mobilize stored energy in the "fight or flight" response. The effect of adrenaline is via a G protein signaling cascade, which transmits chemical signals from outside the cell across the membrane to the inside of the cell (cytoplasm). The outside signal (in this case, adrenaline) binds to a receptor, which transmits a signal to the G protein, which transmits a signal to adenylate cyclase, which transmits a signal by converting adenosine triphosphate to cyclic adenosine monophosphate (cAMP). cAMP is known as a second messenger.^{[1]wikipedia"}
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And I have mentioned that any important gene give a deformity if missing,  this one does.  The name of the deformity

Polyostotic fibrous dysplasia, look it up!

In the brain GNAS-1 dances with important people such as RIC8 which has a nice name to fool you Synembryn-A,

mess with Synembryn A and brace yourself to deal with DGK-1, and EGL-30

to know more ask Klattenhoff!

Klattenhoff C, Montecino M, Soto X, et al. (2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol.". J. Cell. Physiol. 195 (2): 151–7.

That is the pattern of cellular events, "start small and keep amplifying"

----------------------------------------another intermediary we spoke about was GNA12

there we discussed already the role of anti-CD44 and anti-P110 alpha

and its link to HSP90.  

Puzzled? go to article-blog!