GENES IN SARCOMA (LISTED FIRST AND THEN WE GO TO WORK!)

THE C-KIT CASE

ACTIVATES THE FOLLOWING GENES
PIK3R1
PLCG1
SH2B2/APS
CBL
THE POTENT GRB2
RAS/MAPK
PTPN6/SHP1
PTPRU
CRK
LYN
SRC
SHC1
DOK1
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TEC   Very significant target because down the stream of this gene is DOK1,and most impressively ARHGEF which has activity with 2 well recognised therapeutic targets CD44 and P110 alpha, remember P110alpha deficiency can induce Malformation (Macrocephaly) and you know how we feel about gene inducing malformation

" non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.<sup>[2]wikipedia

Anti CD44 has just been used in a recent publication

adding a booster of c-AMP may intensify the effect (PRKAR1A related)</sup>
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PREDISPOSING GENES
NF1
LI-FRAUMENI
HELICASE GENES
P53
CYTOKINES/KITLG/SCF

SPECIFIC GENES FOR SOME SPECIFIC SARCOMA

1.GIST        C-KIT, CD 117, PDGFR-ALPHA
2.ALVEOLAR RHABDOMYOSARCOMA PAX3-FOXO1A
3.EWING SARCOMA   EWSR1-FLI1 AND EWSR-ERG
4.LIPOSARCOMA CDK4,HDM2
5.SYNOVIAL SYT-SSX1,2
6.MYXOID FUS-CHOP DDIT3