YOU WANT TO TRY SOMETHING NEW AGAINST SARCOMA AND LEUKEMIA
GO AFTER THESE GENES!

SATB1

From Wikipedia, the free encyclopedia

Jump to: navigation, search

SATB homeobox 1
PDB rendering based on 1yse.
Available structures PDB Ortholog search: PDBe, RCSB [show]List of PDB id codes
Identifiers
Symbol	SATB1
External IDs	OMIM: 602075 MGI: 105084 HomoloGene: 2232 GeneCards: SATB1 Gene
[show]Gene Ontology
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6304	20230
Ensembl	ENSG00000182568	ENSMUSG00000023927
UniProt	Q01826	Q60611
RefSeq (mRNA)	NM_001131010	NM_001163630
RefSeq (protein)	NP_001124482	NP_001157102
Location (UCSC)	Chr 3: 18.39 – 18.49 Mb	Chr 17: 51.74 – 51.83 Mb
PubMed search	[1]	[2]

SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene.^[1]

Function

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation.^[2] Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli.^[3] At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1 has also been shown to induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.

Interactions

SATB1 has been shown to interact with HDAC1,^[4] SMARCA5,^[4] MTA2,^[4] CHD4,^[4] CUTL1,^[5] POLR2J^[6] and BAZ1A.^[4]

2. HDAS1
3.SMARCA5
4.MTA2
5.CHD4
6.CUTL1
7.POLR2J
8.BAZIA