IN METASTATIC DISEASE THAT IS ADVANCED, ONE OF THE GENE MENTIONED IS THE NME1/NM23A

This gene (Non Metastatic Cell 1) is expressed at 17q21.3 and produces protein NM23A.Contrary to its name, it is noted to be expressed in advanced Metastatic disease and as such could have prognosis indication.
Remember, there is that notion that if a Molecule found in Metastatic state is present in the early stage of a cancer, it is predictive of more advanced cancer, higher recurrence rate and higher mortality risk.