Wednesday, May 1, 2013

A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses

A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses

Geoffrey S Diemer and Kenneth M Stedman*
GO to the article ! 

This story truly deserve the reward given to those scientists
it is the story introducing the 9th law of nature
which is the law of adaptation to unusual conditions by adjusting genetic potential, by the power of recombination, and using cellular heterogeneity, and by activating NF-kB.
cells have an incredible versatility potential if given the time and if the programmed death is not triggered by an overwhelming stimulant... to adapt and develop new function ready to deal with change in the environment.  These changes could be dramatic! ie we lost our tail for god sake!
The reversal of mesenchymal transformation is another of change to adaptation and is the underlying reason of deviation of epithelialization driving the Barrett transformation in the lower 3rd of the Esophagus.  These changes are benign until receptor become desensitized to an overwhelming and relentless stimulation leading to the HSP (heat stroke protein ) gets as well as the provoked!  Prevention of progression to cancer should dampen growth factors and decrease HSP actions!
We have recently hypothesized that the MEK action  as well as the Wnt were membrane located and followed the Reticulum Endothelium tract to reach the nucleus.   With the involvement of the Hedgehog, Basaloid morphology resulted in triple negative breast cancer!  (Again if it is strong enough to induce a morphologic change, it is strong enough to cause an abnormality so significant as a neoplastic process.-even Fanconi abnormality associated with morphology changes (microcephaly) will lead to a Myelodysplastic  Syndrome.  (and we contend that these type of syndrome will respond to Revlimid and Thalidomide type of drugs).  We promise to discuss the gene involved in the 9th law soon but this text tells you already where we are going to fish them!
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