Monday, February 29, 2016

In life, All go in pathways

If you understands that life is hidden in pathways, you know half of the truth...and yes if you can touch A and B you may finally reach C and later on Z.   The price is really how much perspicacity you intend to put up....and how much surprises you intend to unveil!
The Brain is hidden in the skull, and lives of Oxygen and sugar (no transformation of fat here if any).  Therefore gene that intervene in Oxygenation and de-Oxygenation are critical.  A  little known gene called IDH-1 gene is important!
"The protein encoded by this gene is the NADP+-dependent isocitrate .... "Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors"."  wikipedia

This gene most found with the Mitochondria and probably the protosome intervene in the detoxification of the cell.  But why is this gene important in the all scheme of Brain cancer and leukemia.  The point is to ultimately find the connection of this gene with how much it is linked to expression of genes.  Indeed remember many gene messages are hidden by methylation.Well methylation is a phenomenon that is very NADP like or dependent phenomenon.   Therefore Methylation of genes within the Brain cell is very affected by IDH-1 gene mutation.   IDH-1 will involve Cytosine based molecules such as TET gene, the initiation point of Methylation/de-Methylation of genes...Just imagine if this happen in a Telomere (which affect aging)...the cell all of the sudden will have its   aging changed or tempered with.   This is happening in both Leukemia and Brain cancer...and may be certain Sarcomas.

Life is a continuum...Starting from particle before the atoms, How this is linked to planets and into the Universe remains a question that goes deep into the truth of life!

Temodar and 5 AZAcitidine works in these diseases...proof in the pudding....

Thursday, February 18, 2016

And it goes on

With millions of suns in our Gallaxy (the Milky way )chances are there could be
a earth like life comparable to ours.   But given the randomness of Circumstances that need to be met for our existence, the chance of finding other human beings remains remote.
Water, Oxygen and right composition of Oxygen based gazes need  to be gathered to lead to us like beings.
and why Dinosaurs did not return after the earth return to life,
because evolution occurs one way or the other given the circumstances?
So imagine one particular planet where Helium was the predominant gas,  the organism that will grow if any, may be the yellow man or green man that may result...or is it another dinosaur that will not survive even if we meet!   now come the question, should we meet at all?
I keep looking for now into Orion!

It gets complicated

from Myriad"Myriad’s newest companion diagnostic, myChoiceTM HRD, is an algorithmic measurement of three biomarkers associated with homologous recombination deficiency, combined with next-generation sequencing of the BRCA1 and BRCA2 genes in the tumor.  The three biomarkers, loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state transitions (LST), have all been individually shown to be associated with BRCA1/2 deficiency.1"

Monday, February 15, 2016

Life Mysteries

Before you read this, take a moment to reflect about life as it is a mystery
Mystery in its being, extent, dimensions and even purpose ...The truth is in every which way
you look at it...the mystery of life goes on.
I was thinking about planets ...what is their purpose, are they "alive", why are they so many, do they still have some form life that we cannot define.
The distance to the sun, the distance between the planet, how far is "Pegasus" and the planets of Orion or Sirius etc...all this is measured in dimensions that are difficult to comprehend.  One thing is for sure, many have agreed that we are under the influence of the moon.  That our mood swings with it, that our ocean's wind changes with there a message we are unable to understand...Is there a "pulse" to earth or other planets.   We know something wakes up Volcanoes or earth quakes but we still don't know what (and how to predict) earth a living being?
One thing for sure not only we do not pay attention enough to things around us (It took me over 50 years to start my interest in the stars) but also the secrets or mysteries of life is kept by many things including our lifespan.   When we look at life at planet level, 100 years is meaningless...we die before we can actually learn enough...even the batteries on the hubble Telescope last may be 30 years...They will die before we discover more...our best minds such as Einstein perished before greater revelations were made.  The mystery is preserved because a continuum is broken each time a researcher dies!
Are we not replacing our researchers?  yes we are but do they have the same fervor and caliber...that we can debate...the same goes when we look into genes,  researchers drop the ball sometime when they reach world recognition ...they sometimes just waste away...because of their age may be ...and the truth remains hidden....We have to keep on going...more mysteries await...