Monday, April 4, 2016

Chromosome Translocation, an old scientific curiosity

From Myelodysplasia to most cancers including T cell lymphoproliferative disorder, scientific readings continue to report how chromosomal translocations have such a prognosis meaning for our patients.   They go on to tell us how "breakable" these locations on the chromosome are...
"Loss of Heterozygosity (LOH) is identified in 30 to 60% commonly at 9p,10q, 1p, and 17p"...in cutaneous T cell Lymphomas  (Kuzel et al)
what most literatures does not report is just as important, but may be more important, is the specific gene really involved by the translocations.
for 5q deletion syndrome, a Myelodysplasia, the gene appears to have been discovered so that we can develop new Medicine aside from Revlimid, and may be understand a little more what induce the disease and what can be done more specifically...defining what a chromosomal deletion involves in terms of gene missing or criss-crossing appears more urgent now.

"Recently,RPS14 has been identified as a likely candidate gene involved in the 5q-syndrome" (ASCO)

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