FOLLOWING UP ON THE 3RD LAW. (SWING OF THE PENDULUM)

WITH CELL DIFFERENTIATION AT ONE EXTREME, AND CELL PROLIFERATION AT THE OTHER SIDE.  During Malignant transformation, the pendulum swings from de-differentiation to proliferation.  Pushing the EXIT-door open.  At the molecular level, there is an increased expression of genes involved in promoter regulation (TTK, E2F1), but also a gene is involved with the resumption of mitotic phases BUB1, MCM2,CDC.  Microfilament formation and Histone related molecules also reappear ((NUSAP1,ZWINT,CENPA), but also CEP55, CKAP).  Activity at the promoter region is proven by overexpression of EZH.  Relevent cyclins involved are proven by activation of CDKN2 .   Over-expression of any combination of these genes marks the first sign of a Cancerous trend in a differentiated cell.

Of all these, E2F1 and NUSAP-1 seem to be the focus of target therapy as interactions with HMGA are suggested in the literature!