This is definitively informative for those looking who are looking for a comprehensive presentation of target of therapy. We will review the m-TOR today!

These diagrams have been assembled by Cell Signaling Technology (CST) scientists and outside experts to provide succinct and current overviews of selected signal transduction pathways. Knowledge about each signaling pathway has been synthesized and integrated into understandable paradigms of cellular communication. Please send suggestions for developing new pathways to info@cellsignal.com.
The proteins in each pathway are linked to a search on the PhosphoSitePlus^® website, which is an expert-curated knowledge base of protein phosphorylation plus other post-translational modifications in vertebrates. A matching collection of product search pathways is also online.

Requirements: Using these pathways requires JavaScript and the free Adobe Flash Player version 10 or higher. To view the pathway PDFs, you will need the free Adobe Acrobat Reader.

Chromatin / Epigenetic Regulation

• Protein Acetylation
• Histone Methylation
• Examples of Crosstalk Between Post-Translational Modifications
• Histone Modification Table

MAP Kinase Signaling

• Mitogen-Activated Protein Kinase Cascades
• MAPK/Erk in Growth and Differentiation
• G-Protein-Coupled Receptors Signaling to MAPK/Erk
• SAPK/JNK Signaling Cascades
• Signaling Pathways Activating p38 MAPK

Apoptosis

• Apoptosis Overview
• Inhibition of Apoptosis
• Death Receptor Signaling
• Mitochondrial Control of Apoptosis

Autophagy

• Autophagy Signaling

PI3 Kinase / Akt Signaling

• PI3K / Akt Signaling
• PI3K / Akt Binding Partners Table
• PI3K / Akt Substrates Table

Cellular Metabolism

• Insulin Receptor Signaling
• AMPK Signaling
• Warburg Effect

Translational Control

• Translational Control: Overview
• Translational Control: Regulation of eIF2
• Translational Control: Regulation of eIF4E and p70 S6 Kinase
• mTOR Signaling

Cell Cycle / DNA Damage

• Cell Cycle Control: G1/S Checkpoint
• Cell Cycle Control: G2/M DNA Damage Checkpoint

Immunology and Inflammation

• Jak/Stat Signaling: IL-6 Receptor Family
• Jak/STAT Utilization Table
• Jak and Cytokine Receptor Mutants in
  Cancer Table
• NF-κB Signaling
• TLR Pathway
• B Cell Receptor Signaling
• T Cell Receptor Signaling

Neuroscience

• Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
• Dopamine Signaling in Parkinson's Disease

Stem Cells, Development, and Differentiation

• Wnt/β-Catenin Signaling
• Notch Signaling
• Hedgehog Signaling In Vertebrates
• TGF-β Signaling
• Hippo Signaling
• ESC Pluripotency and Differentiation

Cytoskeletal Regulation and Adhesion

• Regulation of Actin Dynamics
• Regulation of Microtubule Dynamics
• Adherens Junction Dynamics

Other

• Angiogenesis
• ErbB/HER Signaling
• Ubiquitin/Proteasome
• Ubiquitin Ligase Table

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This is definitively informative for those looking who are looking for a comprehensive presentation of target of therapy.   We will review the m-TOR today!