LBK-1 GENE AND CAVEOLIN DISRUPTION

Some women have a clear tendency to have Multiple calcifications or  Microcalcifications in the Breast.  And we know that clusters of calcifications found on mammograms, call for a Biopsy of the involved area.  Disruption of the shape of the epithelium is known to be associated with Mutation of LBK-1 as stated in our previous blog.

GUANGWEN CAO ET AL STATED:
"Caveolin-1 (Cav1) is a major structural protein of caveolae, small membrane invaginations of the cell membrane that play a cell and context-dependent role in potocytosis, transcytosis, molecular transport, and signal transduction. ^1,2 Specific molecules from four major signaling pathways have been detected in caveolae, G-protein mediated signaling, calcium-mediated signaling, tyrosine kinase/mitogen-activated protein kinase signaling, and lipid signaling. Caveolae appear to be a focal point for compartmentalizing, organizing, and modulating signal transduction activities that begin at the cell surface and Cav1 may function not only as a structural molecule but also to modulate the function of signal transduction pathways. ²'

CALVEOLIN-1 HAS BEEN ASSOCIATED WITH URINARY STONES.

Are disruptions at LBK-1 and Cav-1 associated with benign multiple calcification in the breast?  And is their presence a predictor of DCIS and/or early breast cancer?