TALKING DE-ACETYLATION, PANOBINOSTAT

Panobinostat is a De-acetylator inhibitor for Histone, meaning that it paralyzes a few enzymes perinuclearly, therefore blocking Mitosis this way.
It has demonstrated Activity in Relapsed/Refractory Hodgkin's disease post transplantation. An area where it does not have much competition.   And here it is actually pretty good at achieving like most target therapies a 30% effectiveness and  with additional stable diseases.  A respectable effectiveness.
Now  it is being tried in Non Hodgkin's disease with Rituxan.  We will update you on this!