Showing posts with label endothelial changes. Show all posts
Showing posts with label endothelial changes. Show all posts

Monday, March 11, 2013

AVASTIN and Blood Vessels


1. Avastin normalizes blood vessel and therefore improves drug delivery
2.Combination with anti-EGFR, shortens PFS
3. Changes endothelium
4. Refractoriness soon develops
5.no cures
6.lack of biomarkers to optimally evaluate,monitor efficacy, and therefore dose optimally
7.Increasing Fibroblast growth factor as a way of dealing with lack of VEGF receptors
?dummy receptor to hijack extracellular - transcription factors increase