Showing posts with label metalloproteinases. Show all posts
Showing posts with label metalloproteinases. Show all posts

Sunday, October 14, 2012

CLINICAL HYPOTHESIS IN CANCER RESEARCH AND COMMERCIALIZATION:

CLINICAL HYPOTHESIS IN CANCER RESEARCH AND COMMERCIALIZATION:

Of 186,000 Prostate cancers diagnosed each year, only 29,000 patients will die of this disease. In fact 70% of men over 80 years of age may be found with Prostate Cancer.  Most will not die of this cancer. This fact has made almost futile the testing for prostate cancer in elderly patients.  How does one chose who should be followed closely or treated? In other words how do you know what prostate cancer to observe versus which one to actually treat? In more scientific terms, which are the predictive factors that would prompt us to act versus observe the cancer? To make the matter more confusing, the success of PSA (prostate Specific Antigen) testing has complicated the issue.  It has led to over-diagnosis, and experts are now recommending to use PSA findings with caution.
One thing is for sure: the difference between a benign and malignant tumor is that the malignant ones spread and invade our body. This  is called "ability to metastasize".  It is by invading other organs that cancer causes these organs to fail and finally causing death of the patient.  Researchers have now started to look at cancer cells to try to predict which ones will spread and therefore kill the individual.

The Hypothesis:

For a cancer to spread, it has to detach itself from its surroundings and  create a way to where it wants to go. Scientists have suggested that wherever a cell is located, it is maintained in place by ADHESION MOLECULES which tie them to the location.  To make its move, the cancer cell has to lose these molecules.
This is why E-Cadherin has to be reduced by the cell, so that it can free itself from this environment. The question now is:  Is a REDUCTION OF E-CADHERIN A PREDICTOR OF BAD CANCER? IN OTHER WORDS, SHOULD WE BE TESTING FOR THE REDUCTION OF E-CADHERIN IN PROSTATE CANCER TO PREDICT WHICH ONES NEEDS INTERVENTION?  This is thought provoking.
P120 and beta- catenins are 2 molecules which could potentially be surrogates of cancer metastasis...who knows for sure!

After it has freed itself,  the cancer cell has to move through tissues, it uses enzymes to break through the fibers. Some of these enzymes are called METALLOPROTEINASE. The current question is: SHOULD WE BE MEASURING LEVELS OF METALLOPROTEINASES TO DETECT CANCER CELLS ON THE MOVE?

Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro

Eleni Apostolidou1*)

These questions have been raised, it is time to work.
We could actually improve current means of screening for cancer by checking for reduction of E-Cadherin and increase of metalloproteinase in the tumor or blood if this is possible.  Potential for commercialization is high if we can conquer this detection technology.  "lets go to work! 
 
12/3/2012

METASTATASIS AND SEEDING INTO NEW OR INVADED TISSUE

When the cancer cell reaches the new location, it uses the TGF beta to help its growth and to create exceptional advantage for its growth versus surrounding tissue.   This Lead scientists to conclude that TGF beta presence is a sign of resistant disease.   When in facts,  it is first a late sign of metastasis already COMPLETED, TGF beta seems to be a sign of SEEDING INTO A NEW LOCATION.  TGF BETA NOT ONLY STIMULATE GROWTH BUT COULD BE AN INHIBITORY PROTEIN FOR THE HOST DEFENSE AND REJECTION.

QUESTION:

SHOULD TGF BETA INCREASE BE THE THE SIGN OF SEEDING VS LATE STEP OF METASTASIS. WE BELIEVE THAT BY THE TIME TGF BETA IS BEING ELEVATED, SEEDING HAS ALREADY OCCURRED.