REPROGRAMMING OR MESENCHYMALIZATION.
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1. MET
---------------It is center to cancer preparing for Metastasis.
Once the initial cause of cancer have hit the cell, and the cancer cell wants to migrate because of several reasons such as stress in that location, lack of Oxygen or nutrients, the cancer cell is ready to find another location to increase its chance of survival. Most cancer develop within the lining of ducts of tube like part of the organs (Bowel, breast ducts, pancreatic duct, endometrial cancer etc) therefore they are epithelial. But epithelial cell do not migrate well, they are tied up to neighboring cell to make somewhat of a seal. That is they use plenty of adhesion molecule to anchor down the basal membrane and the immediately surrounding cell. To start moving, they have to rejuvenate and try to re-acquire the early version that brought them there in the first place. They came from MESENCHYMAL cells. AND THE DOOR TO GO FROM MESENCHYMAL TO EPITHELIAL CELL PASS THROUGH MET! MET IS THE REVOLVING DOOR. IT IS ONLY THROUGH MET THAT METASTASIS CAN OCCUR, ESTAHLISH ITSELF, AND STABILIZE IN NEW LOCATIONS. REMEMBER MET CAN AMPLIFY VEGF FOR NEW BLOOD SUPPLY TO THE NEW TUMOR LOCATION!
TO FIND OUT MORE, Please go to:
Published in Volume
119, Issue 6 (June 1, 2009)
J Clin Invest. 2009;119(6):1429–1437. doi:10.1172/JCI36183. Copyright © 2009, American Society for Clinical Investigation Review SeriesBiomarkers for epithelial-mesenchymal transitions |
c-RET
c-ROS
2. c-MYC
Role of Rho-GTPase
PARAXIS
Resistance to EGFR
Oct 4
Klf4
SOX 2 Vs SOX 9(in Chorndrosarcoma)
Nanog
E-cadeherin,
syndecan-1
Claudins
B-catenin
Occludin-1 (Zo-1)
Other EpCam
Crumbs
homolog-3
Snails (Slug)
Zeb
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FSP-1
SRC
RAS
fos
HSP47
Fibrobalaste transcrition site
CBF-A
Carg Box Binding Factor
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TGF beta
NT-3
Sonic Hedgehop
alpha 5 beta 1 Integrin
----------------------
alpha SMA stress fibers,
DDR2
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cell spindle shape
AXL
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Collagen, Vimentin, laminin, fibronectin
