Saturday, January 3, 2015

about Vitamin D

Dr David Samadi:
"A University of Colorado Cancer Center study recently published in the journal Prostate presents new evidence that vitamin D may help reduce cancer-causing inflammation. Scientists found that the gene GDF-15 – known to be up-regulated by vitamin D - can help block a protein which stimulates tumor growth." (suppression of the NFkB?)

from WebMD:

" The pigment melanin reduces the skin's ability to make vitamin D in response to sunlight exposure. Some studies show that older adults with darker skin are at high risk of vitamin D deficiency."

Is this why Prostate cancer tend to be more aggressive in Black
Is this sufficient evidence that Vitamin D deficiency should be avoided to reduce cancer
what is the role of Vitamin D in reducing certain Cytokines
does Vitamin D deficiency play a role in other cancers?
what is the role of Vitamin D in altering the Telomeres?
should Vitamin D enter the main stay of treatment of Metastatic Prostate cancers  (particularly in black)

While the NFkB may be involved, the truth is  everything  seems to happen at the Vitamin D receptor .
We know that in certain cases of deficiency (induced by Cytokines), the cell will increase the receptors to maximize its chances of capturing the Vitamin. And this may be the first move to neoplastic transformation.   Indeed increase in unbound Receptors of Vitamin D will overactivate not only the WNT but the deadly Hedgehog signaling changing the shape of the the prostate and its fate or life.   Just the BAG-1 (BCL-2 interaction) stimulation that will ensue is sufficient to beat the drum of Neoplasia.    Subsequent disruptions including  of Cav3, Raf, the RUNX and so forth will ensue.  Leading to a full fledged prostate cancer....by the way this receptor also interacts with the AR (Androgen Receptor).     Avoid Vitamin D deficiency by all costs!  (The scenario where desensitization of Vitamin D receptor is the alternative is not discussed here)
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