Tuesday, March 29, 2016

Striking Facts

*Mutation of BRAF has been seen in all cases of Hairy cell Leukemia
Is that mean that Cladribine  and Pendostatin need to be used in BRAF positive Melanoma
or is this a different BRAF

The opposite is it true? should we use dabrafenib in Hairy cell Leukemia

Are they localized Mutations that differentiate the 2 types of BRAF Mutations...

*As it stands,  CLL treatment include
-Chlorambucil +/- Rituxan (or Ofatumumab/Obinutuzumab), R-CHOP
-Rituxan Bendamustine
-Idelalisib, the anti PI3K
- CARTs targeting CD19
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