SMAD4: Co-factor of TGF Beta, involved in Juvenile Polyposis syndrome, mutation lead to a form of dwarfism and pulmonary hypertension
S100-P; important for cell differentiation and progression, through the EZRIN, it participate in lighting PI3K pathway. It also participate in propagation of Osteosarcoma
NFAT: Uses calmodulin-calcineurin pathways to drive to specific transcription factors for growth and invasion particularly in breast cancer. It the site of action of Cyclosporine as it disturbance mislocate immune modulating cyclins and growth factors. NFAT3 inhibits Lipocalin 2 expression to blunt the cell invasion.
PRKCG: remind us that the pancreas is heavily full of nerve. whether this is the origin of pains from the pancreatic cancer is a question, but through PICK1, it links this to mitochondrial function/membrane
remember the role of Mitochondria, pancreas and glucolysis, this connection to the mitochondria raises questions in all kind of directions, further investigation is needed here... " be involved in neuropathic pain development. Defects in this protein
have been associated with neurodegenerative disorder spinocerebellar
ataxia-14 (SCA14).
[3]" (wikipedia)
MLL3: binds to the Core Binding factor like molecule for blood and neuron differentiation. T
his CBF contain Retinoblastoma protein 5 therefore interfere with a stop in cell division
but also involve THIS!
NCOA6
From Wikipedia, the free encyclopedia
Nuclear receptor coactivator 6 is a
protein that in humans is encoded by the
NCOA6 gene.
[1][2][3]
The
protein encoded by this gene is a
transcriptional coactivator that can interact with
nuclear hormone
receptors to enhance their transcriptional activator functions. The
encoded protein has been shown to be involved in the hormone-dependent
coactivation of several receptors, including prostanoid, retinoid,
vitamin D
3, thyroid hormone, and
steroid
receptors. The encoded protein may also act as a general coactivator
since it has been shown to interact with some basal transcription
factors,
histone acetyltransferases, and
methyltransferases.
[3]"
Making MLL3 a huge target! although disruptions here may have implication on all cells.
BETA 4 INTEGRIN: a gene that does more than being an adhesion molecules
it is the road to a poorly described and not well recognized pathway
The LysRS-Ap4A-MITF signaling pathway
The
LysRS-Ap
4A-MITF signaling pathway was first discovered in
mast cells, in which , the
MAPK pathway
is activated upon allergen stimulation. Lysyl-tRNA synthetase (LysRS),
which normally resides in the multisynthetase complex with other
tRNA sythetases, is phosphorylated on
Serine 207 in a MAPK-dependent manner.
[30]
This phosphorylation causes LysRS to change its conformation, detach
from the complex and translocate into the nucleus, where it associates
with the MITF-HINT1 inhibitory complex. The conformational change
switches LysRS activity from aminoacylation of Lysine tRNA to
diadenosine tetraphosphate (Ap
4A) production. Ap
4A binds to HINT1, which releases MITF from the inhibitory complex, allowing it to transcribe its target genes.
[31] Activation of the LysRS-Ap
4A-MITF signaling pathway by
isoproterenol has been confirmed in cardiomyocytes, where MITF is a major regulator of cardiac growth and
hypertrophy.
[32][33](wikipedia)
Not only it gives Hypertrophy but epidermolysis goes through this intergrin, it participates in the ERBB pathways. Mark my word this is are critical pathways in pancreatic cancers.
MTIF GIVES YOU MOTIVES TO AFTER IT!
MAKING THE ERBIN A PLAUSIBLE TARGET.
MAKING ALSO A STRONGER CASE THAT MEMBRANE CYTOSKELETON SHOULD BE A GOOD TARGET BECAUSE OF THE WAY IT DRIVES ITS PATHWAY NOT THROUGH THE CYTOSOL( ALTHOUGH THERE IS A SECONDARY RAS/MAPK STIMULATION,) BUT THE PATHWAY HERE IS THROUGH THE RETICULUM ENDOTHELIUM DIRECTLY TO THE NUCLEUS! CONCEPTUALLY, AN ANTIBODY TO LAMININ ATTACHED TO A SUBUNIT OF A LIPOLYTIC COMPOUND SHOULS HAVE AN THERAPEUTIC OR CHEMICAL EFFECT AT THIS LEVEL. AN INTERESTING APPROACH. CHANCES ARE IT MAY ALSO HAVE A STRONG IMPACT ON THE WNT-PATHWAY WHICH TRAVEL CLOSE BY AND IS IMPORTANT IN BREAST CANCER!
MTA-1: THIS IS A REAL OPPORTUNITY
Here the cell stopped fooling around trying to lie to you. Here the cell says to you this is one of my way to metastatasize. yes this is my gene to mestastasize and I will work like any CBF like molecule by attaching to DNA and make me protein that will have me spread like wild fire! And by the way I will use a growth hormone like Estrogen. no kidding around
"MTA1 has been shown to
interact with
HDAC1,
[4][5] Histone deacetylase 2,
[4][6][5] MTA2,
[4] Estrogen receptor alpha[7][5] and
MNAT1.
[8] MTA1 has also been shown to inhibit SMAD7 at the transcriptional level[9]
"
IT DOES NEED TGF TO WORK, TGF IS FOR LOCAL GROWTH ANYWAY THAT WHY IT BLOCKS THE SMAD.
SPINT2
Mutation at SPINT2 leads to significant Malignant Ascites and peritoneal invasion, SPINT 2 is a suppressor of this phenomena. On the Intestinal membrane deficiency of SPINT2 leads to sodium induced/containing diarrhea. This is also true in Ovarian cancer or peritoneal based tumors. Targeting this is better then trying Avastin, a blind approach when it comes to effusions management.
MMP11
A metalloproteiase, aimed at breaking down extracellular matrix and be on the move. Targeting MMP for cancer has proven futile. The cell is not stupid, it does not put out things that is going to hunt it! It build first a strong inhibitor to metalloproteiases. In fact lack of inhibitors has been recognized as the main pathogenesis of TTP. With the ADAMs being the integrins involved! and next is that Inhibitor which is of course expressed in pancreatic cancer.
TIMP1
TIMP1
From Wikipedia, the free encyclopedia
TIMP metallopeptidase inhibitor 1, also known as
TIMP1, a
tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.
This protein a member of the
TIMP family. The
glycoprotein is a natural
inhibitor of the
matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the
extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote
cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
==============
PRKCA see PRKCG
Here Phorbol esters, diacylglycerol, and calcium become important for the cell performance of various functions. Did I mention few targets, I truly believe I did!
CDH1 The Cadherin by excellence, not only important as adhesion molecule and role in metastasis. Its role is amplified by what else anchors here such as Vinculin, and others molecules such as Plakoglobins, amplifying the role. Remember even Cytochrome C is anchored at the mitochondrial membrane and its release leads to apoptosis!
The anchors are legitimate targets therefore, and brings to mind NACA1 in the anchoring to Histone deacetyl transferase (SEE OUR LEUKEMIA SECTION) CDH13 THAT'S ANOTHER BALL GAME ALL TOGETHER. THE CELL TWEACKS SOMETHING AND IT IS ANOTHER BALL GAME ALL TOGETHER!
==========================
ALOX5AP
ACVR1B
PCD1
IRS2
TJP1
MADH6
