Sunday, March 17, 2013


SMAD4:  Co-factor of TGF Beta, involved in Juvenile Polyposis syndrome, mutations lead to a form of dwarfism and pulmonary hypertension

S100-P; important for cell differentiation and progression, through the EZRIN, it participates in lighting PI3K pathway.  It also participates in propagation of Osteosarcoma.

NFAT:  Uses calmodulin-calcineurin pathways to drive to specific transcription factors for growth and invasion particularly in breast cancer.  It the site of action of Cyclosporine as its disturbance mislocates immune modulating cyclins and growth factors. NFAT3 inhibits Lipocalin 2 expression to blunt the cell invasion.
PRKCG: reminds us that the pancreas is heavily full of nerves. Whether this is the origin of pains from the pancreatic cancer is a question, but through PICK1, it links this to mitochondrial function/membrane.
Remember the role of Mitochondria, pancreas and glycolysis,  this connection to the mitochondria raises questions in all kind of directions,  further investigation is needed here... " be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).[3]" (wikipedia)
MLL3:  binds to the Core Binding factor like molecule  for blood and neuron differentiation.  T
his CBF contains Retinoblastoma protein 5 therefore interfere with a stop in cell division
but also involve THIS!


From Wikipedia, the free encyclopedia
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Nuclear receptor coactivator 6
Symbols NCOA6; AIB3; ASC2; NRC; PRIP; RAP250; TRBP
External IDs OMIM605299 MGI1929915 HomoloGene40920 GeneCards: NCOA6 Gene
RNA expression pattern
PBB GE NCOA6 208979 at tn.png
More reference expression data
Species Human Mouse
Entrez 23054 56406
Ensembl ENSG00000198646 ENSMUSG00000038369
UniProt Q14686 A2AQM9
RefSeq (mRNA) NM_001242539 NM_001242558
RefSeq (protein) NP_001229468 NP_001229487
Location (UCSC) Chr 20:
33.28 – 33.41 Mb
Chr 2:
155.39 – 155.47 Mb

PubMed search [1] [2]

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]"

Making MLL3 a huge target! although disruptions here may have implication on all cells.
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