Major implication of the Gli-1

I.  The Gli-1 gene
affects the following other genes
---PDGFR in mesenchymal tissue
---FOXM1
---Sufu
---SP1, USF1
---Twist1
---CyclinD2
---Plakoglobulin
---Shh

II. PTCH1:  Act as a receptor to the Hedgehog ---the contact releases the SMO
Revant Info-Vismodegib
"The substance acts as a cyclopamine-competitive antagonist of the smoothened receptor (SMO) which is part of the hedgehog signaling pathway.^[2] SMO inhibition causes the transcription factors GLI1 and GLI2 to remain inactive, which prevents the expression of tumor mediating genes within the hedgehog pathway.^[4] This pathway is pathogenetically relevant in more than 90% of basal-cell carcinomas.<sup>[5]"wikipedia

link to chondrosarcoma is most puzzling
role in bladder cancer still to be explored, mostly I guess in the squamous type?
in Medulloblastoma?</sup>

Focus on Peroxisome

Peroxisomes IPA: [pɛɜˈɹɒksɪˌsoʊmz]^[1] (also called microbodies) are organelles found in virtually all eukaryotic cells.^[2] They are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, D-amino acids, polyamines, and biosynthesis of plasmalogens, i.e. ether phospholipids critical for the normal function of mammalian brains and lungs.^[3] They also contain approximately 10% of the total activity of two enzymes in the pentose phosphate pathway, which is important for energy metabolism.^[3] It is vigorously debated if peroxisomes are involved in isoprenoid and cholesterol synthesis in animals.^[3] Other known peroxisomal functions include the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves,^[4] glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.(Wikipedia)
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 with our discussion on the PEX26 and Sufu, we are working on opportunities of interventions through the peroxisome!

The Crux of Tumorgenesis

The secret of cancer proliferation and persistence lays in phenomena at the membrane, where the NOTCH, Wnt and Hedgehog are located.  These functions of the membrane start and drive the cancer with help from the ABCG2, MRp1, Pgp gene;  it gives it resistance to powerful medications (Adriamycin, CPT11), with SuFu/PEX it reaches a gene capable of inducing malformation, with FOXM1, proliferation is guaranteed, through GLI1, Cyclin D2 is reached. Differentiation is reached though the MEK and failure of control is assured by dysregulation at the FAK.  The Cancer's mind set is driven by the FOXM1 for sure.  Other genes involve the NANOG, the PTCH1, The SOX and the OCT, CDH1, Shh,Twist, Plakoglobulin...