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WE ARE PROUD TO ANNOUNCE THAT WE HAVE BEEN INVITED TO PRESENT AND DEFEND OUR POSTER RELATED TO TRAUMATIC BRAIN INJURY (TBI) : EARLY USE OF BUTEIN, A SIRTUIN ACTIVATOR IN TRAUMATIC BRAIN INJURY!
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Showing posts with label butein. Show all posts
Showing posts with label butein. Show all posts
Thursday, November 14, 2013
Monday, February 25, 2013
A WELL STUDIED MOLECULE!
BUTEIN
1. It is a natural Chalconoid, derived from Toxicodendron Vernicifluum
2. It is inhibitor of EGFR and SRC Tyrosine Kinase, Please give it in all Adenocarcinoma ...(in a trial of course! and at your own expenses and risk!)
3.Inhibitor of c-AMP dependent processes
4. Induce Apoptosis in B16 Melanoma cells and in HL60 Leukemia cells.
5. Anti-inflammatory
6. An Aldolase Reductase
7. An Aromatase inhibitor, please give it in ER positive Breast Cancer
8. a chelator of Iron and Cupper, please give it in Hemosiderosis in a clinical trial
9. Inhibitor of NF-kB and TNF inhibitor, that's how it is an anti-inflammatory
(try it in Sepsis gone overboard-in clinical trial). MD Anderson claimed it does this by Inhibiting IKK, check it out!
10. Activator of Sirtuins, the stuff you give to stop Dementia! Sirtuins that you take to preserve survival through Telomere protection. Oh by the way Sirtuins are Histone Deacetylators! do the math and consequence calculation. It will add to the MTOR inhibitors!
11, Increase activity of Caspase 3, Increase activity of BAX, and decrease BCL-2 to lead to Apoptosis of cancer cells talked about above!
12. Inhibitor of Glutation reductase
Please I have to stop here, These are just too much goodies!
I will be taking this Butein myself!
I guess you can relax now!
Believe me, people take Butein to treat their Gastric Cancers even!
BUTEIN
1. It is a natural Chalconoid, derived from Toxicodendron Vernicifluum
2. It is inhibitor of EGFR and SRC Tyrosine Kinase, Please give it in all Adenocarcinoma ...(in a trial of course! and at your own expenses and risk!)
3.Inhibitor of c-AMP dependent processes
4. Induce Apoptosis in B16 Melanoma cells and in HL60 Leukemia cells.
5. Anti-inflammatory
6. An Aldolase Reductase
7. An Aromatase inhibitor, please give it in ER positive Breast Cancer
8. a chelator of Iron and Cupper, please give it in Hemosiderosis in a clinical trial
9. Inhibitor of NF-kB and TNF inhibitor, that's how it is an anti-inflammatory
(try it in Sepsis gone overboard-in clinical trial). MD Anderson claimed it does this by Inhibiting IKK, check it out!
10. Activator of Sirtuins, the stuff you give to stop Dementia! Sirtuins that you take to preserve survival through Telomere protection. Oh by the way Sirtuins are Histone Deacetylators! do the math and consequence calculation. It will add to the MTOR inhibitors!
11, Increase activity of Caspase 3, Increase activity of BAX, and decrease BCL-2 to lead to Apoptosis of cancer cells talked about above!
12. Inhibitor of Glutation reductase
Please I have to stop here, These are just too much goodies!
I will be taking this Butein myself!
I guess you can relax now!
Believe me, people take Butein to treat their Gastric Cancers even!
Tuesday, February 5, 2013
BUTEIN, A POWERFUL INHIBITOR
As we speak with the University of Texas in El Paso, the CRBCM would like to look further into the clinical use of a potent Inhibitor in a phase I study. We believe this compound will have a significant role in Triple Negative Breast Cancer. Butein, a derivative of Charcone, a powerful anti-Oxidant and known anti-inflammatory used in ASIA, seems to have a global inhibitory effect. It is one of the 3 inhibitors of the SRC, it is a Glutathione inhibitor, Blocker of EGF, inhibitor of IKK, and of the NF-kB signal transduction pathway, cause phosphorylation of the AKT, reduction of Cyclin D1 and D2, activation of WAF1/p21 and KIP1/p27, Iron induced inhibitor of Xanthine Oxidase (love that enzyme since I first learned about Asthma).
This Butein stuff is a global inhibitor. If you add this to MTOR inhibitors, you may end up with too toxic a combination for any cancer! This would be an overwhelming attack on cells!
It has demonstrated powerful Ex-vivo activity against breast and prostate cancer cell lines, and is empirically used against Gastric cancer.
This global and versatile inhibitor, Butein, should have activity in Sarcoma since it inhibits SRC and potentially the fibroblast. Other Inhibitors of SRC, heme supported phosphorylation and CYIKYYF. (of note CDK1, PTRC and PTK2)
Gave you so many letters, lets move to gene Nomenclature please! we are still working hard at the CRBCM!
This Butein stuff is a global inhibitor. If you add this to MTOR inhibitors, you may end up with too toxic a combination for any cancer! This would be an overwhelming attack on cells!
It has demonstrated powerful Ex-vivo activity against breast and prostate cancer cell lines, and is empirically used against Gastric cancer.
This global and versatile inhibitor, Butein, should have activity in Sarcoma since it inhibits SRC and potentially the fibroblast. Other Inhibitors of SRC, heme supported phosphorylation and CYIKYYF. (of note CDK1, PTRC and PTK2)
Gave you so many letters, lets move to gene Nomenclature please! we are still working hard at the CRBCM!
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