Researchers from the Memorial Sloan K. have confirmed the principle that reading phenomena at the cell membrane you could predict recurrence and prognosis of cancer. They looked at patients with stage I lung cancer (earliest stage) and could predict recurrence based on concentration of membrane receptors to IL 12 and IL7.  We know that increased Growth factor Receptor promote cancer cell in an autocrine fashion.  This finding seems to reinforce this knowledge.  We have discussed the GLYCOCALYX, activity of the Flipase/Flopase and other changes that may attract the Macrophage.  We also have shown that through the Caspase 8, membrane occurring phenomena could induce Apoptosis without nuclear involvement.
Focusing on membrane activity take you also to the Calmodulin and initiation of signal pathways.  All is happening at the membrane, and a focus at these changes is warranted!