EVENTS GOVERNING CELLULAR LIFE

Overall, life at the cellular level enters a new phase as the sperm enters the Ovocyte, here the activity of life is driven by Nuclear events; cell division (and motility of cells) is the driving trend of forces to be amplified and the Embryo formation (Embryogenesis) is the ultimate objective.  As the embryo is being formed, there a transition of forces from proliferation to tissue differentiation. This transition from PROLIFERATION with an AMPLIFIED MITOSIS AND MOVEMENT OF CELL FOR POSITIONING IN THE BODY OF THE EMBRYO characterizes early life and is driven by promoter genes, amplified pathways, driven metabolism at Ribosome, histone, and genetic levels.  The processing of internal and external stimuli triggers the flow of forces.  A change of stimuli eventually occurs, followed by responses imposed by growth factors, variation in needs, and overall  cellular communications, and soon enough the trend of forces is toward differentiation.  In order to protect future life, SANCTUARY tissues are created to keep DIVISION POTENTIAL ACTIVE (Ovaries, testicles keep proliferative potential and controlled activity).   DIFFERENTIATION becomes the name of the game and is AMPLIFIED.  To commit resouces to this activity exclusively, proliferation is shut down at genes, enzymes, and chromatin levels to shield proliferation related  promoters.  Tissue differentiation is pushed to allow life, survival and adaptation leading to races and other phenotypic differentiation.  Each step is amplified to perfection (whatever the perfection is or implied).  REPRESSION OF A GENE THAT NORMALLY SHOULD BE AMPLIFIED OR STAT TRANSCRIPTION UNDER THESE CIRCUMSTANCES, MEANS ONCOGENIC SUPPRESSION AND A SIGN OF MALIGNANT PROLIFERATION AND POTENTIALLY ASSOCIATED RESUMPTION OF MITOSIS AND MIGRATION (METASTASIS).  IT IS ALSO ASSOCIATED WITH LOSS OF DIFFERENTIATION AND ATYPICAL PHENOTYPIC TRANSFORMATION.

This implies that whenever cancerous trending forces are triggered, they happen in a cell which will de-differentiate, but will switch to proliferation, mobility and perfect for survival and adaptation.  A cell trained to escape mechanism of local and distant defense, and full of survival and adaptation skills!  The ESCAPE include eluding local attacks by change in receptors, glycocalyx and level of pump and MDR gene expression,   but also distant (escape Anoikis) cell rejection.

Cancer is a formidable opponent with so many opportunities for target intervention if you know where to touch or block the flow of things for the cure.  The timing of change of the flow of forces/trends provides as much opportunity as a check point.  One may want to target these events.

CURE IS POSSIBLE WHEN YOU LOOK AT THIS WAY OF THINKING!

WITH EVERY LAW COMES A SET OF SPECIFIC GENES, ENZYMES, REGULATORS, PATHWAYS AND POTENTIAL DRIVERS, WE WILL HUNT THEM, STUDY THEM AND DEVELOP TARGET THERAPY OVER THE NEXT FEW YEARS, FEEL FREE TO DO THE SAME, THE RACE IS ON!!!!!

Researchers from the Memorial Sloan K. have confirmed the principle that reading phenomena at the cell membrane you could predict recurrence and prognosis of cancer. They looked at patients with stage I lung cancer (earliest stage) and could predict recurrence based on concentration of membrane receptors to IL 12 and IL7.  We know that increased Growth factor Receptor promote cancer cell in an autocrine fashion.  This finding seems to reinforce this knowledge.  We have discussed the GLYCOCALYX, activity of the Flipase/Flopase and other changes that may attract the Macrophage.  We also have shown that through the Caspase 8, membrane occurring phenomena could induce Apoptosis without nuclear involvement.
Focusing on membrane activity take you also to the Calmodulin and initiation of signal pathways.  All is happening at the membrane, and a focus at these changes is warranted!

AMAZING GLYCOCALYX
CELL SUGAR COATING!

One of the wonders of the cell is its sugar coating.  Indeed this fine layer of mostly sugar component serves many functions to the cell.  From adhesion to other cells to providing signals to the surrounding milieu.  It is given to that sugar coating the responsibility to find the cell location in our tissues during global positioning in the embryo, sperm locating of the egg to fertilize, and recognition of bacteria passing by in the blood.
Glycocalyx, the sugar coat of the cell, plays a major role in cancer, it is one of the ways the immune system recognizes the early change of a normal cell to a cancer cell.  If changes in Glycocalyx are not striking enough to be noticed by our immune surveillance, cancer will be allowed to survive.  The other change of course involves the receptors on the cellular membranes.
How well our immune system detects the change depends on the status of that immune system, and how big of a change has occurred to the Glycocalyx as a result of malignant transformation.  Studying the changes in receptors and Glycocalyx can help us locate and selectively hit the cancer cell while sparing the normal cell.
Sugar coating glycocalyx !