Showing posts with label NCI. Show all posts
Showing posts with label NCI. Show all posts

Wednesday, February 6, 2013

RENAL CANCER PREVENTION (CHRONIC USE OF DECONGESTANT -AFRIN- COULD DECREASE RENAL CANCER.) and so does a CPAP mask for patients with Sleep Apnea

Renal cell cancer risk is associated to smoking and Obesity (hypertension is a corollary risk we claim).   These 2 conditions lead to Hypoxia generally through sleep Apnea  which in turn leads to a relative increase of Hemoglobin. The rise of Hemoglobin increases the portion of Desaturated hemoglobin. After many years of such exposure desaturated Heme enhances Phosphorylation at Tyr-530 of the SRC leading to its deactivation. In some individuals with the right MEK, suppression pf the SRC could lead to persistent amplification at the MEK which is a versatile activator of almost all signals, but particularly VEGF receptor.  This in turn usually lead to papillary cancers. Amplification of signal transduction started at the MEK (which amplifies almost all major known pathways) will lead to increased ubiquitination and proteasome destruction of the HYPOXIA-inducible factor  (following the Von Hippel-Lindau model.  This will lead to clear cell cancer. Associated desaturated Heme and hypoxia at the mitochondria will participate in the transformation (and possibly the Atypia/clear cell transformation).  The preponderance and center piece role of MEK amplification and subsequent VGEF/PDGF will justify the "bloody" nature of kidney cancers, and vessel involvement in these diseases  (MEK is the driver Mutation in papillary cancers).  IT ALSO EXPLAINS WHY SUTENT, NEXAVAR WORKS.  AND MITOCHONDRIAL DISTURBANCES AND SECONDARY AMPLIFICATION OF AKT, THE MTOR INHIBITORS WORK IN RENAL CANCERS  (MTOR participates more in clear cells)  (proof of concept pending)

In Western society, obesity is increasing, and so is Sleep Apnea.  Also, we live in closed homes (in some regions such as Texas and Louisiana, Mosquitoes are not helping) the level of dust participates in the increased level of allergic Rhinitis/ upper respiratory ailments.  It is not unusual to sleep and wake with closed Nostrils.  In obese individuals, this compounds the hypoxic episodes and worsened and prolonged hypoxia.  And we are back to depression of SRC, activation of MEK---akt, MAPK and so forth.
Keeping your nostrils open at night appears to be a critical strategy in preventing renal cancer, particularly in patients with breathing issues.   Lung cancer may be reduced for non smokers, but I wont touch that speculation, but do remember the role of VEGF in non-smoker lung cancers!

The involvement of PDGF which is by the way affected by Sutent seems to open a window in the frequency of strokes and heart attacks at night!  That's another debate to have...!

MTOR inhibitor in combination with Anti-VGEF/ MEK could have a significant role in non smoker lung cancer.?
Velcade could have a role in VHL prevention ? and in Pheochromocytoma?

Avastin and Mtor inhibitor could treat Leiomysarcoma of the Uterus if you follow this logic!

A FREED CPRIT AND THE NIH COULD HELP!

Saturday, December 15, 2012

CPRIT MAY LOSE NCI SEAL OF APPROVAL!

The NCI announced that federal officials are looking into events at CPRIT.  It is unclear whether their evaluation will only lead to recommendations about the NCI seal of approval status, or whether they are searching for federal crimes at CPRIT.  Our fear for CPRIT's future is that a broader investigation will expose more irregularities in grant allocations, and that more people will be charged with criminal misconducts.  Voters were right to vote for CPRIT funding. Cancer needs to be met at higher intensity.  What voters  did not predict was that CPRIT will end up being taken over by "evil people" or "vultures and hyenas" in the words of a renowned Nobel Laureate who worked there.  What needs to occur at CPRIT is a complete purge which should change leardership and culture at CPRIT.  CRBCM would like to be invited to the conversation about the future of CPRIT.   We believe that broader measures and safeguards need to be implemented to not only preclude failures in grant allocations, but also to make sure CPRIT is more inclusive and responsive to minority concerns.  CPRIT has funded mainly Universities and Biotech companies in a race where even underdogs should be allowed to come up with the right ideas and should be given a chance!  CRBCM is such an underdog!   It is interesting to note that the departing chief executive wants to stay on until the next round of grant allocation.  The CRBCM is worried that his participation will be detrimental to our cause since we voiced our opinion.  It also will be ground for our next appeal. Let it be known!