KNOW THIS: A little bit of good news in the nation !

"Diabetes report card chronicling how the United States is faring in terms of management of the condition in adults, based on data to 2010, shows that there has been improvement, but there are still large gaps in terms of the control of 2 important risk factors, smoking and hypertension." (Medscape)".

DOES HAIR COLOR CHANGE COMES FROM METHIONINE MALABSORPTION ???

DOES HAIR COLOR CHANGE COMES FROM METHIONINE MALABSORPTION ???

"The following Votrient side effects are common (occurring in greater than 30%) for patients taking Votrient:

• Diarrhea
• Hypertension
• Hair color changes
• Low blood counts (low white blood cells, low platelets)
• Elevated liver function tests (AST, ALT)
• Elevated bilirubin level
• Blood test abnormalities (low phosphorus, low sodium, increased glucose) 

These are less common side effects (occurring in 10-29%) for patients receiving Votrient:

• Nausea
• Vomiting
• Poor appetite
• Fatigue
• Weakness
• Abdominal pain
• Headache
• Blood test abnormalities
• Low Magnesium
• Low Glucose - Low Blood Sugar

This list includes common and less common side effects for those taking Votrient. Votrient's side effects that are very rare -- occurring in less than about 10 percent of patients -- are not listed here. Always inform your health care provider if you experience any unusual symptoms."

(SCOTT HAMILTON CARES )

Adverse event: Diarrhea - General Guidelines by Pfizer

Adverse event

Description

General guidelines

Diarrhea

Diarrhea is an abnormal increase in stool liquidity

and frequency (4 to 6 stools or more per day

over baseline) with or without nocturnal bowel

movements and/or moderate abdominal

cramping. Diarrhea is a common side effect of

many cancer regimens. It can cause depletion of

fluids and electrolytes, malnutrition, dehydration,

and hospitalization and therefore can interfere

with cancer treatment, causing dosing delays or

reductions.

1

Patient education strategies

•

Emphasize the importance of maximizing oral

hydration strategies to avoid dehydration and

electrolyte imbalances

2

•

Educate patients about the likelihood that diarrhea

will develop

3-5

Management tips for patients

•

Diarrhea may be managed through diet as well

as pharmacologic treatment when necessary,

based on the clinical judgment of the treating

healthcare provider (HCP).

1,3,4

The first step in

treatment is dietary management

3,5,6

:

–

Yogurt containing probiotics

–

Soluble fiber

–

Small but frequent meals

–

Fluids, such as water, diluted cranberry juice,

broth, decaffeinated tea or coffee

•

Over-the-counter and Rx agents may also be

used, according to labeling

1,3,4

Hypertension

Hypertension is the term used to describe high blood

pressure (BP). In general, hypertension is repeated

BP elevation exceeding 140 mm Hg systolic blood

pressure (SBP) and 90 mm Hg diastolic blood

pressure (DBP).

7

Hypertension is a commonly

reported AE in cancer patients receiving antivascular

endothelial growth factor (VEGF) drugs.

8

Patient education strategies

•

Take antihypertensive medications as prescribed

4

•

Recognize signs of potentially dangerous

high BP (eg, severe headache, shortness of

breath, nosebleeds)

9

•

Follow healthy lifestyle choices: regular exercise,

weight control, moderate alcohol consumption,

sodium restriction

4

RENAL CANCER PREVENTION (CHRONIC USE OF DECONGESTANT -AFRIN- COULD DECREASE RENAL CANCER.) and so does a CPAP mask for patients with Sleep Apnea

Renal cell cancer risk is associated to smoking and Obesity (hypertension is a corollary risk we claim).   These 2 conditions lead to Hypoxia generally through sleep Apnea  which in turn leads to a relative increase of Hemoglobin. The rise of Hemoglobin increases the portion of Desaturated hemoglobin. After many years of such exposure desaturated Heme enhances Phosphorylation at Tyr-530 of the SRC leading to its deactivation. In some individuals with the right MEK, suppression pf the SRC could lead to persistent amplification at the MEK which is a versatile activator of almost all signals, but particularly VEGF receptor.  This in turn usually lead to papillary cancers. Amplification of signal transduction started at the MEK (which amplifies almost all major known pathways) will lead to increased ubiquitination and proteasome destruction of the HYPOXIA-inducible factor  (following the Von Hippel-Lindau model.  This will lead to clear cell cancer. Associated desaturated Heme and hypoxia at the mitochondria will participate in the transformation (and possibly the Atypia/clear cell transformation).  The preponderance and center piece role of MEK amplification and subsequent VGEF/PDGF will justify the "bloody" nature of kidney cancers, and vessel involvement in these diseases  (MEK is the driver Mutation in papillary cancers).  IT ALSO EXPLAINS WHY SUTENT, NEXAVAR WORKS.  AND MITOCHONDRIAL DISTURBANCES AND SECONDARY AMPLIFICATION OF AKT, THE MTOR INHIBITORS WORK IN RENAL CANCERS  (MTOR participates more in clear cells)  (proof of concept pending)

In Western society, obesity is increasing, and so is Sleep Apnea.  Also, we live in closed homes (in some regions such as Texas and Louisiana, Mosquitoes are not helping) the level of dust participates in the increased level of allergic Rhinitis/ upper respiratory ailments.  It is not unusual to sleep and wake with closed Nostrils.  In obese individuals, this compounds the hypoxic episodes and worsened and prolonged hypoxia.  And we are back to depression of SRC, activation of MEK---akt, MAPK and so forth.
Keeping your nostrils open at night appears to be a critical strategy in preventing renal cancer, particularly in patients with breathing issues.   Lung cancer may be reduced for non smokers, but I wont touch that speculation, but do remember the role of VEGF in non-smoker lung cancers!

The involvement of PDGF which is by the way affected by Sutent seems to open a window in the frequency of strokes and heart attacks at night!  That's another debate to have...!

MTOR inhibitor in combination with Anti-VGEF/ MEK could have a significant role in non smoker lung cancer.?
Velcade could have a role in VHL prevention ? and in Pheochromocytoma?

Avastin and Mtor inhibitor could treat Leiomysarcoma of the Uterus if you follow this logic!

A FREED CPRIT AND THE NIH COULD HELP!

 Lifestyle measures (FROM THE BRITISH HYPERTENSION GUIDELINES)

• Maintain normal weight for adults (body mass index 20-25 kg/m²)
• Reduce salt intake to < 100 mmol/day (< 6g NaCl or <2.4 g Na⁺/day)
• Limit alcohol consumption to ≤ 3 units/day for men and ≤ 2 units/day for women
• Engage in regular aerobic physical exercise (brisk walking rather than weightlifting) for ≥ 30 minutes per day, ideally on most of days of the week but at least on three days of the week
• Consume at least five portions/day of fresh fruit and vegetables
• Reduce the intake of total and saturated fat
  ============================================
  FOR BREAST CANCER PATIENTS, REDUCING CARBOHYDRATE INCREASES DISEASE FREE PROGRESSION MEANING ONCE YOU HAVE COMPLETED PRIMARY TREATMENT, YOU STAY FREE OF DISEASE LONGER IF YOU TAKE LESS CARBOHYDRATES.  THIS HAS BEEN VALIDATED!