AML-1 mostly corresponds to the alpha subunit of the CBF and contains the RUNX-1 which specializes in hematologic differentiation of the cell, the other portion already contains among other things regulatory or catalytic molecules facilitating many processes of the cell combination with EVI-1 will control signal pathways and growth factors.
This type of AML, or AML in general, appears to be a disease mostly driven by dysregulation of promoters and regulator genes with global suppression of the NK-kB a nd the cyclins/TGF.
?role of ANDROGEN, interferon and growth factor in EVI-1 positive AML can be raised as a question. On top of standard induction chemotherapy of course! This is where Cyclosporine and Antithymocyte Globulin could still have a role (in EVI-1 AML)
One may wonder why TGF is suppressed? Maybe to stop the cancerous process to form a mass and stay "fluid"? That is, in granulocytic sarcoma, TGF would be less suppressed?
Showing posts with label hematologic differentiation. Show all posts
Showing posts with label hematologic differentiation. Show all posts
Monday, March 4, 2013
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