BASIC SCIENCE QUESTIONS

Should patients with lymphoproliferative disorders avoid Alcohol since LMRP positivity suggests COOH  involvement?
Can pain at lymph nodes in Hodgkin disease after ingestion OF ALCOHOL or pruritus predict the presence of LMRP mutation?
Is the pruritus in Hodgkin disease linked to the presence of COOH at the nerve terminal?
Should we treat lymphoproliferative disorders with LRMP expression with Cisplatin etoposide based therapy?

Interleukin-4 is the best protective Interleukin of all, I wonder if we should be measuring it as a prognosis factor in  Lymphoproliferative disorders? Is overexpression of HGAL or GCET2 a corollary indication of IL-4 activity?

Questions in Hodgkin Disease

QUESTIONS IN HODGKIN DISEASE

1.WHY A BIMODAL INCIDENCE BY AGE ?
2.WHY HX OF MONONUCLEOSIS INCREASES 3X THE RISK OF HODGKIN DISEASE ?
3.THE INFECTIOUS PROCESS MUST LEAVE A DEFICIENCY FOR HODGKIN LYMPHOMA TO DEVELOP (HIV, EBV,  BONE MARROW TRANSPLANT) ?CD8, HLA DR (ACQUIRED IMMUNITY) ?
4.DOES EXTRANODAL INFILTRATION MEAN T-CELL INVOLVEMENT OR JUST FAILURE OF A BLOOD VESSEL ?
(to be continued)