Showing posts with label lymph nodes. Show all posts
Showing posts with label lymph nodes. Show all posts

Saturday, November 2, 2013

BASIC SCIENCE QUESTIONS

Should patients with lymphoproliferative disorders avoid Alcohol since LMRP positivity suggests COOH  involvement?
Can pain at lymph nodes in Hodgkin disease after ingestion OF ALCOHOL or pruritus predict the presence of LMRP mutation?
Is the pruritus in Hodgkin disease linked to the presence of COOH at the nerve terminal?
Should we treat lymphoproliferative disorders with LRMP expression with Cisplatin etoposide based therapy?

Interleukin-4 is the best protective Interleukin of all, I wonder if we should be measuring it as a prognosis factor in  Lymphoproliferative disorders? Is overexpression of HGAL or GCET2 a corollary indication of IL-4 activity?

Friday, January 18, 2013

NEW LIPOSOMAL VINCRISTINE WITH EFFICACY IN RELAPSE/REFRACTORY PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

AT 2.25 MG/m2 IV WEEKLY
COMPLETE REMISSION RATE 4.6%
WITH OF COURSE NEUROPATHY IN ALMOST 40% OF PATIENTS
BUT EFFECTIVE EVEN WITHOUT ASPARAGINASE
Liposomal encapsulation prolongs its presence in the blood and ability to penetrate the marrow, lymph nodes and spleen).
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Jakafi, for your Myelofibrosis patient with positive JAK2V617F positive and negative patient
with a 35% reduction in splenomegaly at 24 weeks occurring in 41% of patients.
will check out the JAK signaling!