EVENTS GOVERNING CELLULAR LIFE

Overall, life at the cellular level enters a new phase as the sperm enters the Ovocyte, here the activity of life is driven by Nuclear events; cell division (and motility of cells) is the driving trend of forces to be amplified and the Embryo formation (Embryogenesis) is the ultimate objective.  As the embryo is being formed, there a transition of forces from proliferation to tissue differentiation. This transition from PROLIFERATION with an AMPLIFIED MITOSIS AND MOVEMENT OF CELL FOR POSITIONING IN THE BODY OF THE EMBRYO characterizes early life and is driven by promoter genes, amplified pathways, driven metabolism at Ribosome, histone, and genetic levels.  The processing of internal and external stimuli triggers the flow of forces.  A change of stimuli eventually occurs, followed by responses imposed by growth factors, variation in needs, and overall  cellular communications, and soon enough the trend of forces is toward differentiation.  In order to protect future life, SANCTUARY tissues are created to keep DIVISION POTENTIAL ACTIVE (Ovaries, testicles keep proliferative potential and controlled activity).   DIFFERENTIATION becomes the name of the game and is AMPLIFIED.  To commit resouces to this activity exclusively, proliferation is shut down at genes, enzymes, and chromatin levels to shield proliferation related  promoters.  Tissue differentiation is pushed to allow life, survival and adaptation leading to races and other phenotypic differentiation.  Each step is amplified to perfection (whatever the perfection is or implied).  REPRESSION OF A GENE THAT NORMALLY SHOULD BE AMPLIFIED OR STAT TRANSCRIPTION UNDER THESE CIRCUMSTANCES, MEANS ONCOGENIC SUPPRESSION AND A SIGN OF MALIGNANT PROLIFERATION AND POTENTIALLY ASSOCIATED RESUMPTION OF MITOSIS AND MIGRATION (METASTASIS).  IT IS ALSO ASSOCIATED WITH LOSS OF DIFFERENTIATION AND ATYPICAL PHENOTYPIC TRANSFORMATION.

This implies that whenever cancerous trending forces are triggered, they happen in a cell which will de-differentiate, but will switch to proliferation, mobility and perfect for survival and adaptation.  A cell trained to escape mechanism of local and distant defense, and full of survival and adaptation skills!  The ESCAPE include eluding local attacks by change in receptors, glycocalyx and level of pump and MDR gene expression,   but also distant (escape Anoikis) cell rejection.

Cancer is a formidable opponent with so many opportunities for target intervention if you know where to touch or block the flow of things for the cure.  The timing of change of the flow of forces/trends provides as much opportunity as a check point.  One may want to target these events.

CURE IS POSSIBLE WHEN YOU LOOK AT THIS WAY OF THINKING!

WITH EVERY LAW COMES A SET OF SPECIFIC GENES, ENZYMES, REGULATORS, PATHWAYS AND POTENTIAL DRIVERS, WE WILL HUNT THEM, STUDY THEM AND DEVELOP TARGET THERAPY OVER THE NEXT FEW YEARS, FEEL FREE TO DO THE SAME, THE RACE IS ON!!!!!