Showing posts with label gene amplification. Show all posts
Showing posts with label gene amplification. Show all posts
Thursday, August 22, 2013
Processes of cancerization
One of the most intriguing steps in the neoplastic transformation is determining the actual event that led to its occurrence. We all have the perception that because of what we ingest unfortunately on a continuous basis (medications or foods we like - man clings to habits) something will get either amplified or suppressed. Certain amplifications can be deleterious or beneficial depending of where they occur or what gene is involved. It is apparent that involvement of "wild genes" (those with multiple interactions with others, including genes involved in shaping the body) are more likely to lead to malignant transformation (ie. the Androgen gene, FYN,Grb2, MTIF, etc). Secondly, knocking out break to proliferation (P53, Rb1, PTEN, and the many CDK) seems also to be a prelude to a neoplastic transformation. Alteration in "switch" genes (SOS) and molecules intermediary to various cellular/membrane events can also trigger a persistent stimulation or suppression that could affect cellular processes enough to upset a balance. Chronic hypoxia has emerged to be a potent neoplastic process inducer....(to be continued)
Thursday, January 24, 2013
EVENTS GOVERNING CELLULAR LIFE
Overall, life at the cellular level enters a new phase as the sperm enters the Ovocyte, here the activity of life is driven by Nuclear events; cell division (and motility of cells) is the driving trend of forces to be amplified and the Embryo formation (Embryogenesis) is the ultimate objective. As the embryo is being formed, there a transition of forces from proliferation to tissue differentiation. This transition from PROLIFERATION with an AMPLIFIED MITOSIS AND MOVEMENT OF CELL FOR POSITIONING IN THE BODY OF THE EMBRYO characterizes early life and is driven by promoter genes, amplified pathways, driven metabolism at Ribosome, histone, and genetic levels. The processing of internal and external stimuli triggers the flow of forces. A change of stimuli eventually occurs, followed by responses imposed by growth factors, variation in needs, and overall cellular communications, and soon enough the trend of forces is toward differentiation. In order to protect future life, SANCTUARY tissues are created to keep DIVISION POTENTIAL ACTIVE (Ovaries, testicles keep proliferative potential and controlled activity). DIFFERENTIATION becomes the name of the game and is AMPLIFIED. To commit resouces to this activity exclusively, proliferation is shut down at genes, enzymes, and chromatin levels to shield proliferation related promoters. Tissue differentiation is pushed to allow life, survival and adaptation leading to races and other phenotypic differentiation. Each step is amplified to perfection (whatever the perfection is or implied). REPRESSION OF A GENE THAT NORMALLY SHOULD BE AMPLIFIED OR STAT TRANSCRIPTION UNDER THESE CIRCUMSTANCES, MEANS ONCOGENIC SUPPRESSION AND A SIGN OF MALIGNANT PROLIFERATION AND POTENTIALLY ASSOCIATED RESUMPTION OF MITOSIS AND MIGRATION (METASTASIS). IT IS ALSO ASSOCIATED WITH LOSS OF DIFFERENTIATION AND ATYPICAL PHENOTYPIC TRANSFORMATION.
This implies that whenever cancerous trending forces are triggered, they happen in a cell which will de-differentiate, but will switch to proliferation, mobility and perfect for survival and adaptation. A cell trained to escape mechanism of local and distant defense, and full of survival and adaptation skills! The ESCAPE include eluding local attacks by change in receptors, glycocalyx and level of pump and MDR gene expression, but also distant (escape Anoikis) cell rejection.
Cancer is a formidable opponent with so many opportunities for target intervention if you know where to touch or block the flow of things for the cure. The timing of change of the flow of forces/trends provides as much opportunity as a check point. One may want to target these events.
CURE IS POSSIBLE WHEN YOU LOOK AT THIS WAY OF THINKING!
WITH EVERY LAW COMES A SET OF SPECIFIC GENES, ENZYMES, REGULATORS, PATHWAYS AND POTENTIAL DRIVERS, WE WILL HUNT THEM, STUDY THEM AND DEVELOP TARGET THERAPY OVER THE NEXT FEW YEARS, FEEL FREE TO DO THE SAME, THE RACE IS ON!!!!!
Overall, life at the cellular level enters a new phase as the sperm enters the Ovocyte, here the activity of life is driven by Nuclear events; cell division (and motility of cells) is the driving trend of forces to be amplified and the Embryo formation (Embryogenesis) is the ultimate objective. As the embryo is being formed, there a transition of forces from proliferation to tissue differentiation. This transition from PROLIFERATION with an AMPLIFIED MITOSIS AND MOVEMENT OF CELL FOR POSITIONING IN THE BODY OF THE EMBRYO characterizes early life and is driven by promoter genes, amplified pathways, driven metabolism at Ribosome, histone, and genetic levels. The processing of internal and external stimuli triggers the flow of forces. A change of stimuli eventually occurs, followed by responses imposed by growth factors, variation in needs, and overall cellular communications, and soon enough the trend of forces is toward differentiation. In order to protect future life, SANCTUARY tissues are created to keep DIVISION POTENTIAL ACTIVE (Ovaries, testicles keep proliferative potential and controlled activity). DIFFERENTIATION becomes the name of the game and is AMPLIFIED. To commit resouces to this activity exclusively, proliferation is shut down at genes, enzymes, and chromatin levels to shield proliferation related promoters. Tissue differentiation is pushed to allow life, survival and adaptation leading to races and other phenotypic differentiation. Each step is amplified to perfection (whatever the perfection is or implied). REPRESSION OF A GENE THAT NORMALLY SHOULD BE AMPLIFIED OR STAT TRANSCRIPTION UNDER THESE CIRCUMSTANCES, MEANS ONCOGENIC SUPPRESSION AND A SIGN OF MALIGNANT PROLIFERATION AND POTENTIALLY ASSOCIATED RESUMPTION OF MITOSIS AND MIGRATION (METASTASIS). IT IS ALSO ASSOCIATED WITH LOSS OF DIFFERENTIATION AND ATYPICAL PHENOTYPIC TRANSFORMATION.
This implies that whenever cancerous trending forces are triggered, they happen in a cell which will de-differentiate, but will switch to proliferation, mobility and perfect for survival and adaptation. A cell trained to escape mechanism of local and distant defense, and full of survival and adaptation skills! The ESCAPE include eluding local attacks by change in receptors, glycocalyx and level of pump and MDR gene expression, but also distant (escape Anoikis) cell rejection.
Cancer is a formidable opponent with so many opportunities for target intervention if you know where to touch or block the flow of things for the cure. The timing of change of the flow of forces/trends provides as much opportunity as a check point. One may want to target these events.
CURE IS POSSIBLE WHEN YOU LOOK AT THIS WAY OF THINKING!
WITH EVERY LAW COMES A SET OF SPECIFIC GENES, ENZYMES, REGULATORS, PATHWAYS AND POTENTIAL DRIVERS, WE WILL HUNT THEM, STUDY THEM AND DEVELOP TARGET THERAPY OVER THE NEXT FEW YEARS, FEEL FREE TO DO THE SAME, THE RACE IS ON!!!!!
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