Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation▿†
- Laurence Levy1,
- Michael Howell1,
- Debipriya Das1,
- Sean Harkin1,
- Vasso Episkopou2 and
- Caroline S. Hill1,*
- 1Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom
- 2Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
This is very important because,
1. we are not very good at activating genes, so this is one important way. (all we do is inhibit genes and their protein derivative-that we know!)
2. cancer decreases SMAD to induce lack of proliferation control (through CDK1 for SMAD3 suppression) and disturbance of Ubiquitilation (E3 for SMAD3). Increasing SMAD is taking away cancer "aggressiveness" a new modality of treatment!! very closely followed at CRBCM- This is to be proposed in Metastatic prone diseases such as triple negative breast cancer, pancreatic cancer and few others!
Disruption (suppression) at SMADs is a major biomarker of bad Prostate cancers!!!