other puzzling roles of cytokines!

It is not hard to believe that reactivation of TB under Infliximab therapy would be linked to some cytokine or that pain and increased risk of Achille's tendon rupture following chronic use of Ciprofloxacin would be under the doing by cytokines.  And that any disease state associated with the so called "constitutional symptoms would be also a manifestation of Cytokines'effect.  What surprise the most is how little we do ot care to determine exactly which one.  We instead jump to give NSAID and related compound (steroids or Interferons) without further characterization of these cytokine. No wonder why we meet several side effcts that are unforseen such as increase of strokes and cardiovascular disorders or even bleeding!  Cytokines are notorious in inducing vascular disturbances!  Just ask Wegener or Paget for that matter!